ArticleStructure (London, England : 1993)2009
The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores.
Article in Structure (London, England : 1993), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- Phospho-KNL-1 recognition by a TPR domain targets the BUB-1-BUB-3 complex to C. elegans kinetochores.The Journal of cell biology · 2024Article
- On the Regulation of Mitosis by the Kinetochore, a Macromolecular Complex and Organising Hub of Eukaryotic Organisms.Sub-cellular biochemistry · 2022Article
- Role of Stress-Survival Pathways and Transcriptomic Alterations in Progression of Colorectal Cancer: A Health Disparities Perspective.International journal of environmental research and public health · 2021Review
- Knl1 participates in spindle assembly checkpoint signaling in maize.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Bub1 kinase in the regulation of mitosis.Animal cells and systems · 2021Review
- TGFBR2 mediated phosphorylation of BUB1 at Ser-318 is required for transforming growth factor-β signaling.Neoplasia (New York, N.Y.) · 2020Article
- Recent Progress on the Localization of the Spindle Assembly Checkpoint Machinery to Kinetochores.Cells · 2019Review
- Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosis.Open biology · 2018Review
- Kinases Involved in Both Autophagy and Mitosis.International journal of molecular sciences · 2017Review
- Parallel reorganization of protein function in the spindle checkpoint pathway through evolutionary paths in the fitness landscape that appear neutral in laboratory experiments.PLoS genetics · 2017Article
- The unconventional kinetoplastid kinetochore: from discovery toward functional understanding.Biochemical Society transactions · 2016Review
- Divergent polo box domains underpin the unique kinetoplastid kinetochore.Open biology · 2016Article
- Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfism.Human genetics · 2014Article
- Mad1 kinetochore recruitment by Mps1-mediated phosphorylation of Bub1 signals the spindle checkpoint.Genes & development · 2014Article
- The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregation.Frontiers in physiology · 2014Review
- A TPR domain-containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B.The Journal of cell biology · 2013Article
- Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression.The Journal of cell biology · 2012Article
- On the molecular mechanisms of mitotic kinase activation.Open biology · 2012Review
- Phosphoregulation of Spc105 by Mps1 and PP1 regulates Bub1 localization to kinetochores.Current biology : CB · 2012Article
- Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction.The Journal of cell biology · 2012Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
The interaction of the central mitotic checkpoint component BUB1 with the mitotic kinetochore protein Blinkin is required for the kinetochore localization and function of BUB1 in the mitotic spindle assembly checkpoint, the regulatory mechanism of the cell cycle that ensures the even distribution of chromosomes during the transition from metaphase to anaphase. Here, we report the 1.74 angstroms resolution crystal structure of the N-terminal region of BUB1. The structure is organized as a tandem arrangement of three divergent units of the tetratricopeptide motif. Functional assays in vivo of native and site-specific mutants identify the residues of human BUB1 important for the interaction with Blinkin and define one region of potential therapeutic interest. The structure provides insight into the molecular basis of Blinkin-specific recognition by BUB1 and, on a broader perspective, of the mechanism that mediates kinetochore localization of BUB1 in checkpoint-activated cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.