ArticleJournal of the American Chemical Society2009
Molecular umbrella transport: exceptions to the classic size/lipophilicity rule.
Article in Journal of the American Chemical Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Medical and Nonmedical Applications of Synthetic Transmembrane Anion Transporters.Chemical reviews · 2025Review
- Pd- and Cu-catalyzed approaches in the syntheses of new cholane aminoanthraquinone pincer-like ligands.Beilstein journal of organic chemistry · 2017Article
- Molecular umbrella-amphotericin B conjugates.Bioconjugate chemistry · 2014Article
- Molecular umbrella conjugate for the ocular delivery of siRNA.Bioconjugate chemistry · 2014Article
- Selective cavitand-mediated endocytosis of targeted imaging agents into live cells.Journal of the American Chemical Society · 2013Article
- Synthesis and preclinical evaluation of QS-21 variants leading to simplified vaccine adjuvants and mechanistic probes.Journal of the American Chemical Society · 2012Article
- Opioid glycopeptide analgesics derived from endogenous enkephalins and endorphins.Future medicinal chemistry · 2012Review
- A molecular umbrella approach to the intracellular delivery of small interfering RNA.Bioconjugate chemistry · 2011Article
- Confocal imaging to quantify passive transport across biomimetic lipid membranes.Analytical chemistry · 2010Article
- Protein and small molecule recognition properties of deep cavitands in a supported lipid membrane determined by calcination-enhanced SPR spectroscopy.Journal of the American Chemical Society · 2010Article
- A fine line between molecular umbrella transport and ionophoric activity.Bioconjugate chemistry · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The ability of a series of molecular umbrellas, derived from cholic acid, L-lysine, spermidine, and Cascade Blue, to cross fluid liposomal membranes made from 1-palmitoyl-2-oleyol-sn-glycero-3-phosphocholine (POPC)/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol (POPG) (95/5, mol/mol) has been determined. In sharp contrast to the classic "size/lipophilicity" rule of membrane transport, those molecular umbrellas that were larger in size and less lipophilic crossed these liposomal membranes more readily. The likely origin for this unusual behavior is briefly discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.