ArticleJournal of clinical laboratory analysis2009
Laboratory diagnosis of syphilis with automated immunoassays.
Article in Journal of clinical laboratory analysis, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Sensitivity and Specificity of Treponemal-specific Tests for the Diagnosis of Syphilis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Pooled it
- Improving global estimates of syphilis in pregnancy by diagnostic test type: A systematic review and meta-analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2015Pooled it
- Factors associated with false positive results in serological testing for syphilis using EIA among children.Frontiers in pediatrics · 2025Article
- CDC Laboratory Recommendations for Syphilis Testing, United States, 2024.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2024Article
- Evaluating the diagnostic accuracy of TpN17 and TmpA recombinant proteins in syphilis detection: a phase II study.Frontiers in microbiology · 2024Article
- Syphilis Laboratory Guidelines: Performance Characteristics of Nontreponemal Antibody Tests.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Review
- Urea-mediated dissociation alleviate the false-positive Treponema pallidum-specific antibodies detected by ELISA.PloS one · 2019Article
- Comparison of automated treponemal and nontreponemal test algorithms as first-line syphilis screening assays.Annals of laboratory medicine · 2016Article
- Evaluation of different confirmatory algorithms using seven treponemal tests on Architect Syphilis TP-positive/RPR-negative sera.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- Syphilis testing in blood donors: an update.Blood transfusion = Trasfusione del sangue · 2015Review
- Performance evaluation of the Elecsys syphilis assay for the detection of total antibodies to Treponema pallidum.Clinical and vaccine immunology : CVI · 2015Article
- Comparative evaluation of a new chemiluminiscent assay and an ELISA for the detection of IgM against measles.Journal of clinical laboratory analysis · 2013Article
- Evaluation of the recombinant protein TpF1 of Treponema pallidum for serodiagnosis of syphilis.Clinical and vaccine immunology : CVI · 2013Article
- Evaluation of the BioPlex 2200 syphilis system as a first-line method of reverse-sequence screening for syphilis diagnosis.Clinical and vaccine immunology : CVI · 2013Article
- Public banking of umbilical cord blood or storage in a private bank: testing social and ethical policy in northeastern Italy.Journal of blood medicine · 2013Article
- Europium nanoparticle-based high performing immunoassay for the screening of treponemal antibodies.PloS one · 2013Article
- Evaluation of the Determine Syphilis TP assay for the detection of antibodies against Treponema pallidum for the serodiagnosis of syphilis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Validation of reverse sequence screening for syphilis.Journal of clinical microbiology · 2012Article
- It is time to use treponema-specific antibody screening tests for diagnosis of syphilis.Journal of clinical microbiology · 2012Article
- Analysis of bioplex syphilis IgG quantitative results in different patient populations.Clinical and vaccine immunology : CVI · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The serological detection of specific antibodies to Treponema pallidum is of particular importance in the diagnosis of syphilis. The purpose of this study was to evaluate diagnostic performances of automated immunoassays in comparison with T. pallidum hemagglutination test (TPHA) and Western Blot (WB). The retrospective study was performed with different panels of sera: 244 clinical and serological characterized syphilitic sera and 203 potentially interfering samples. All the sera were tested by Enzygnost Syphilis, ARCHITECT Syphilis TP, TPHA, and homemade WB. The diagnostic performances of the two assays were very similar: both Enzygnost Syphilis and ARCHITECT Syphilis TP performed with a sensitivity of 99.2%, whereas the specificity was 98.5 and 98.4%, respectively. Considering the suitability for automation, both immunoassays may represent a good choice as a screening test. However, the use of a confirmatory test, such as TPHA or WB, remains a must in order to avoid false-positive results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.