Trial reportScandinavian journal of primary health care2009
Salt restriction among hypertensive patients: modest blood pressure effect and no adverse effects.
Trial report in Scandinavian journal of primary health care, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 7 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Blood Pressure Effects of Sodium Reduction: Dose-Response Meta-Analysis of Experimental Studies.Circulation · 2021Pooled it
- Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride.The Cochrane database of systematic reviews · 2020Pooled it
- Effect of dose and duration of reduction in dietary sodium on blood pressure levels: systematic review and meta-analysis of randomised trials.BMJ (Clinical research ed.) · 2020Pooled it
- Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride.The Cochrane database of systematic reviews · 2017Pooled it
- Dietary sodium reduction does not affect circulating glucose concentrations in fasting children or adults: findings from a systematic review and meta-analysis.The Journal of nutrition · 2015Pooled it
- Effect of longer-term modest salt reduction on blood pressure.The Cochrane database of systematic reviews · 2013Pooled it
- Effect of lower sodium intake on health: systematic review and meta-analyses.BMJ (Clinical research ed.) · 2013Pooled it
- Dietary sodium reduction and blood pressure: a dose-response meta-analysis in hypertensive and chronic kidney disease patients.Clinical kidney journal · 2026Article
- Association of sodium intake with diabetes in adults without hypertension: evidence from the National Health and Nutrition Examination Survey 2009-2018.Frontiers in public health · 2023Article
- Salt Restriction in Diabetes.Current diabetes reports · 2015Review
- Dietary sodium and health: more than just blood pressure.Journal of the American College of Cardiology · 2015Review
- Salt: a taste of death?Scandinavian journal of primary health care · 2014Article
- Aldosterone and arterial hypertension.Nature reviews. Endocrinology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePrevious studies, mainly evaluating short-term very low salt diets, suggest that salt restriction may influence glucose and insulin metabolism, catecholamines, renin, aldosterone, and lipid levels adversely. The authors wanted to explore whether sodium restriction for eight weeks influenced insulin secretion unfavourably, and evaluate the efficacy and safety of such treatment also in terms of other parameters important in the management of hypertensive patients.
designA double-blind randomized controlled parallel group designed trial. All participants received dietary advice aimed at a moderate salt-restricted diet. Half of the participants received salt capsules, the others received identical placebo capsules.
settingGeneral practice. SUBJECTS: Forty-six hypertensive patients inadequately controlled by drug treatment.
main outcome measuresFasting serum insulin C-peptide and glucose and levels of these measures after oral glucose, blood pressure, serum aldosterone and lipids, peripheral resistance, and skin conductance.
resultsSalt restriction did not influence glucose and insulin metabolism, aldosterone, or lipid levels adversely. We observed better blood pressure regulation in the low salt group than in the high salt group, with a systolic and diastolic blood pressure difference of 5/5 mmHg after eight weeks. The difference was only statistically significant for diastolic blood pressure, p 0.02.
conclusionThis study revealed a modest diastolic blood pressure reducing effect of moderate sodium restriction. This reduction was obtained without any apparent unfavourable side effects such as increased insulin secretion, impaired glucose tolerance or dyslipidaemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.