MDMA: on the translation from rodent to human dosing.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

1. A Systematic Review of the MDMA Model to Address Social Impairment in Autism.Current neuropharmacology · 2021
   Pooled it
2. Cognitive Effects of MDMA in Laboratory Animals: A Systematic Review Focusing on Dose.Pharmacological reviews · 2019
   Pooled it
3. MDMA-Assisted Treatment for PTSD, Anxiety, and Depression: A Visualized Literature Analysis over 30 Years.Current medicinal chemistry · 2026
   Review
4. Effect of MDMA exposure during pregnancy on cell apoptosis, astroglia, and microglia activity in rat offspring striatum.Iranian journal of basic medical sciences · 2022
   Article
5. MDMA decreases glutamic acid decarboxylase (GAD) 67-immunoreactive neurons in the hippocampus and increases seizure susceptibility: Role for glutamate.Neurotoxicology · 2016
   Article
6. Sensitization to the motor stimulant effects of 3,4-methylenedioxypyrovalerone (MDPV) and cross-sensitization to methamphetamine in rats.Journal of drug and alcohol research · 2016
   Article
7. Inhibition of the dorsomedial hypothalamus, but not the medullary raphe pallidus, decreases hyperthermia and mortality from MDMA given in a warm environment.Pharmacology research & perspectives · 2014
   Article
8. Nonlinear pharmacokinetics of (+/-)3,4-methylenedioxymethamphetamine (MDMA) and its pharmacodynamic consequences in the rat.Drug metabolism and disposition: the biological fate of chemicals · 2014
   Article
9. Independent of 5-HT1A receptors, neurons in the paraventricular hypothalamus mediate ACTH responses from MDMA.Neuroscience letters · 2013
   Article
10. Cognitive impairments from developmental exposure to serotonergic drugs: citalopram and MDMA.The international journal of neuropsychopharmacology · 2013
    Article
11. Paradoxical effects of low dose MDMA on latent inhibition in the rat.Neuropharmacology · 2013
    Article
12. Lost in translation: preclinical studies on 3,4-methylenedioxymethamphetamine provide information on mechanisms of action, but do not allow accurate prediction of adverse events in humans.British journal of pharmacology · 2012
    Review
13. Effect of intermittent exposure to ethanol and MDMA during adolescence on learning and memory in adult mice.Behavioral and brain functions : BBF · 2012
    Article
14. Intermittent ethanol exposure increases long-lasting behavioral and neurochemical effects of MDMA in adolescent mice.Psychopharmacology · 2011
    Article
15. (±)-3,4-methylenedioxymethamphetamine and metabolite disposition in plasma and striatum of wild-type and multidrug resistance protein 1a knock-out mice.Journal of analytical toxicology · 2011
    Article
16. Nonlinear pharmacokinetics of 5-methoxy-N,N-dimethyltryptamine in mice.Drug metabolism and disposition: the biological fate of chemicals · 2011
    Article
17. 3,4-Methylenedioxymethamphetamine (MDMA) alters acute gammaherpesvirus burden and limits interleukin 27 responses in a mouse model of viral infection.Drug and alcohol dependence · 2011
    Article
18. The intriguing effects of ecstasy (MDMA) on cognitive function in mice subjected to a minimal traumatic brain injury (mTBI).Psychopharmacology · 2011
    Article
19. Acute concomitant effects of MDMA binge dosing on extracellular 5-HT, locomotion and body temperature and the long-term effect on novel object discrimination in rats.Psychopharmacology · 2011
    Article
20. The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), methamphetamine and D-amphetamine.Biological chemistry · 2011
    Review

Corrections and comments

• Commented on by
  Comment on the letter by Green, Gabrielsson, Marsden, and Fone, MDMA: on the translation from rodent to human dosing.2009
• Comment on
  The relationship between core body temperature and 3,4-methylenedioxymethamphetamine metabolism in rats: implications for neurotoxicity.2008

Authors and funding

4 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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