ArticleInternational journal of obesity (2005)2009
The interaction of adiposity with the CRP gene affects CRP levels: age, gene/environment susceptibilty-Reykjavik study.
Article in International journal of obesity (2005), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.Circulation · 2011Pooled it
- Leveraging polygenic risk scores to infer causal directions in genotype-by-environment interactions between complex traits.Human genetics · 2026Article
- Socioeconomic position interacts with the genetic effect of a CRP gene common variant to influence C-reactive protein values.Scientific reports · 2024Article
- Rare functional variants in the CRP and G6PC genes modify the relationship between obesity and serum C-reactive protein in white British population.Molecular genetics & genomic medicine · 2023Article
- Quantile-dependent expressivity of serum C-reactive protein concentrations in family sets.PeerJ · 2021Article
- C-reactive protein gene rs1205 polymorphism is associated with low-grade chronic inflammation in postmenopausal women.Women's midlife health · 2020Article
- C-reactive protein gene variants: independent association with late-life depression and circulating protein levels.Translational psychiatry · 2015Article
- Genetic variation across C-reactive protein and risk of prostate cancer.The Prostate · 2014Article
- Genetic risk score and adiposity interact to influence triglyceride levels in a cohort of Filipino women.Nutrition & diabetes · 2014Article
- Haplotypes in the CRP gene associated with increased BMI and levels of CRP in subjects with type 2 diabetes or obesity from Southwestern Mexico.Experimental diabetes research · 2012Article
- C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- Single-nucleotide polymorphisms at five loci are associated with C-reactive protein levels in a cohort of Filipino young adults.Journal of human genetics · 2011Article
- Association study of candidate gene polymorphisms and obesity in a young Mexican-American population from South Texas.Archives of medical research · 2011Article
- Genetic variation in C-reactive protein in relation to colon and rectal cancer risk and survival.International journal of cancer · 2011Article
- Association between adolescent emotional problems and metabolic syndrome: the modifying effect of C-reactive protein gene (CRP) polymorphisms.Brain, behavior, and immunity · 2011Article
- Inflammatory gene variants in the Tsimane, an indigenous Bolivian population with a high infectious load.Biodemography and social biology · 2011Article
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8 authors.
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Abstract
objectiveCommon diseases often have an inflammatory component reflected by associated markers such as serum C-reactive protein (CRP) levels. Circulating CRP levels have also been associated with adipose tissue as well as with specific CRP genotypes. We examined the interaction between measures of body mass index (BMI), waist circumference and fat percent (total fat measured by bioimpedance) with genotypes of the CRP gene in the determination of CRP levels.
methodsThe first 2296 participants (mean age 76+/-6 years, 42% men) in the Age, Gene/Environment Susceptibility-Reykjavik Study, a multidisciplinary epidemiological study to determine risk factors in aging, were genotyped for 10 single nucleotide polymorphisms (SNPs) in the CRP gene. General linear models with age and terms for interaction of CRP genotypes with BMI, waist circumference and percent fat were used to evaluate the association of genotypes to CRP levels (high-sensitivity method, range 0-10 mg l(-1)) in men and women separately.
resultsWe focused on the SNP rs1205 that represents the allele that captures the strongest effects of the gene on CRP levels. Carriers of the rs1205 G allele had significantly higher CRP levels than noncarriers in a dose-dependent manner. Compared to the AA genotype, the slope of the increase in CRP with increasing BMI (P=0.045) and waist circumference (P=0.014) was different for the G allele carriers and of similar magnitude in both men and women. The rs1205 interactions were not significant for fat mass percent, suggesting a possible association with fat localization.
conclusionsThis study further illuminates the known association between measures of adiposity and CRP levels and is shown to be dependent on variation in the rs1205 SNP of the CRP gene. The correlated increase in CRP levels with adiposity is accentuated by presence of the G allele.
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