ArticleHypertension (Dallas, Tex. : 1979)2009
Intrarenal dopaminergic system regulates renin expression.
Article in Hypertension (Dallas, Tex. : 1979), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 48 citations in OpenAlex.
- The choroid plexus is a source of active renin in the central nervous system.Research square · 2026Article
- Inverse Salt Sensitivity of Blood Pressure Is Associated with an Increased Renin-Angiotensin System Activity.Biomedicines · 2022Article
- Effects of Virgin Olive Oil on Blood Pressure and Renal Aminopeptidase Activities in Male Wistar Rats.International journal of molecular sciences · 2021Article
- A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function.Scientific reports · 2019Article
- "I don't get no respect": the role of chloride in acute kidney injury.American journal of physiology. Renal physiology · 2019Review
- Diabetes and Hypertension Differentially Affect Renal Catecholamines and Renal Reactive Oxygen Species.Frontiers in physiology · 2019Article
- The Relationship between the Intrarenal Dopamine System and Intrarenal Renin-angiotensin System Depending on the Renal Function.Internal medicine (Tokyo, Japan) · 2018Article
- Fatty acid receptor modulator PBI-4050 inhibits kidney fibrosis and improves glycemic control.JCI insight · 2018Article
- Lysophosphatidic Acid Receptor Antagonism Protects against Diabetic Nephropathy in a Type 2 Diabetic Model.Journal of the American Society of Nephrology : JASN · 2017Article
- Human GRK4γ142V Variant Promotes Angiotensin II Type I Receptor-Mediated Hypertension via Renal Histone Deacetylase Type 1 Inhibition.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Proximal tubule-derived colony stimulating factor-1 mediates polarization of renal macrophages and dendritic cells, and recovery in acute kidney injury.Kidney international · 2015Article
- Renal dopaminergic system: Pathophysiological implications and clinical perspectives.World journal of nephrology · 2015Review
- Activation of D4 dopamine receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Ciliotherapy: a novel intervention in polycystic kidney disease.Journal of geriatric cardiology : JGC · 2014Article
- Tissue Renin-Angiotensin systems: a unifying hypothesis of metabolic disease.Frontiers in endocrinology · 2014Review
- Gastrin and D1 dopamine receptor interact to induce natriuresis and diuresis.Hypertension (Dallas, Tex. : 1979) · 2013Article
- Physiologic and pathophysiologic roles of cyclooxygenase-2 in the kidney.Transactions of the American Clinical and Climatological Association · 2013Article
- Tubular control of renin synthesis and secretion.Pflugers Archiv : European journal of physiology · 2013Review
- CSF-1 signaling mediates recovery from acute kidney injury.The Journal of clinical investigation · 2012Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Dopamine is a major regulator of proximal tubule salt reabsorption and is a modulator of renin release. Dopamine has been reported to stimulate renin release in vitro through activation of D1-like receptors. However, previous studies investigating dopamine regulation of renin release in vivo have provided contradictory results, indicating stimulation, inhibition, or no effect. We have reported previously that macula densa cyclooxygenase-2 (COX-2) is suppressed by dopamine. Because macula densa COX-2 stimulates renal renin expression, our current studies investigated dopamine regulation of renal renin release and synthesis in vivo. Acute treatment with a D1-like receptor agonist, fenoldopam, significantly inhibited renin release, as did acute inhibition of proximal tubule salt reabsorption with acetazolamide. In catechol-O-methyl transferase knockout (COMT(-/-)) mice, which have increased kidney dopamine levels because of deletion of the major intrarenal dopamine metabolizing enzyme, there was attenuation in response to a low-salt diet of the increases of renal cortical COX-2 and renin expression and renin release. A high-salt diet led to significant decreases in renal renin expression but much less significant decreases in COMT(-/-) mice than wild type mice, resulting in higher renal renin expression in COMT(-/-) mice. In high salt-treated wild-type mice or COX-2 knockout mice on a normal salt diet, fenoldopam stimulated renal renin expression. These results suggest that dopamine predominantly inhibits renal renin expression and release by inhibiting macula densa COX-2, but suppression of renal cortical COX-2 activity reveals a contrasting effect of dopamine to stimulate renal renin expression through activation of D1-like receptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.