ArticleMolecular and cellular biology2009
The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse.
Article in Molecular and cellular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Soluble Uric Acid Drives CD8+ T-cell Exhaustion by Inducing KSR1-Mediated MAPK Hyperactivation.Cancer research · 2026Article
- IQ Domain-Containing GTPase-Activating Protein 1 Regulates Cytoskeletal Reorganization and Facilitates NKG2D-Mediated Mechanistic Target of Rapamycin Complex 1 Activation and Cytokine Gene Translation in Natural Killer Cells.Frontiers in immunology · 2018Article
- To Excavate Biomarkers Predictive of the Response for Capecitabine plus RAD001 through Nanostring-Based Multigene Assay in Advanced Gastric Cancer Patients.Journal of Cancer · 2016Article
- Ultrastructural study of spermatogenesis in KSR2 deficient mice.Transgenic research · 2015Article
- Regulation of RAF protein kinases in ERK signalling.Nature reviews. Molecular cell biology · 2015Review
- The KSR2-calcineurin complex regulates STIM1-ORAI1 dynamics and store-operated calcium entry (SOCE).Molecular biology of the cell · 2014Article
- How MAP kinase modules function as robust, yet adaptable, circuits.Cell cycle (Georgetown, Tex.) · 2014Article
- Kinase suppressor of Ras 1 is not required for the generation of regulatory and memory T cells.PloS one · 2013Article
- Stathmin regulates microtubule dynamics and microtubule organizing center polarization in activated T cells.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-γ production.Gastroenterology · 2011Article
- Article
- Computational analysis of T cell receptor signaling and ligand discrimination--past, present, and future.FEBS letters · 2010Review
- Immunological synapse: a multi-protein signalling cellular apparatus for controlling gene expression.Immunology · 2010Review
- The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse.Immunity · 2009Article
- KSR1 modulates the sensitivity of mitogen-activated protein kinase pathway activation in T cells without altering fundamental system outputs.Molecular and cellular biology · 2009Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
KSR1 is a mitogen-activated protein (MAP) kinase scaffold that enhances the activation of the MAP kinase extracellular signal-regulated kinase (ERK). The function of KSR1 in NK cell function is not known. Here we show that KSR1 is required for efficient NK-mediated cytolysis and polarization of cytolytic granules. Single-cell analysis showed that ERK is activated in an all-or-none fashion in both wild-type and KSR1-deficient cells. In the absence of KSR1, however, the efficiency of ERK activation is attenuated. Imaging studies showed that KSR1 is recruited to the immunological synapse during T-cell activation and that membrane recruitment of KSR1 is required for recruitment of active ERK to the synapse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.