ArticleThe Journal of biological chemistry2009
Transmembrane form agrin-induced process formation requires lipid rafts and the activation of Fyn and MAPK.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- DHCR24Oncogene · 2026Article
- Lipid metabolic reprograming: the unsung hero in breast cancer progression and tumor microenvironment.Molecular cancer · 2025Review
- Agrin Promotes Non-Small Cell Lung Cancer Progression and Stimulates Regulatory T CellsFrontiers in oncology · 2021Article
- Neuroprotection by Neurotropin through Crosstalk of Neurotrophic and Innate Immune Receptors in PC12 Cells.International journal of molecular sciences · 2020Article
- Decoding the Matrix: Instructive Roles of Proteoglycan Receptors.Biochemistry · 2015Review
- LRP4 is critical for neuromuscular junction maintenance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Overcoming barriers and thresholds - signaling of oligomeric Aβ through the prion protein to Fyn.Molecular neurodegeneration · 2013Review
- The role of agrin in synaptic development, plasticity and signaling in the central nervous system.Neurochemistry international · 2012Review
- Ethanol disrupts axon outgrowth stimulated by netrin-1, GDNF, and L1 by blocking their convergent activation of Src family kinase signaling.Journal of neurochemistry · 2012Article
- The glomerular basement membrane.Experimental cell research · 2012Review
- Agrin-signaling is necessary for the integration of newly generated neurons in the adult olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Casting a net on dendritic spines: the extracellular matrix and its receptors.Developmental neurobiology · 2011Review
- Emerging roles for MAP kinases in agrin signaling.Communicative & integrative biology · 2011Article
- Asparagine of z8 insert is critical for the affinity, conformation, and acetylcholine receptor-clustering activity of neural agrin.The Journal of biological chemistry · 2010Article
- Induction of filopodia-like protrusions by transmembrane agrin: role of agrin glycosaminoglycan chains and Rho-family GTPases.Experimental cell research · 2010Article
- The process-inducing activity of transmembrane agrin requires follistatin-like domains.The Journal of biological chemistry · 2010Article
- Dendritic spines and development: towards a unifying model of spinogenesis--a present day review of Cajal's histological slides and drawings.Neural plasticity · 2010Article
- Transmembrane agrin regulates dendritic filopodia and synapse formation in mature hippocampal neuron cultures.Neuroscience · 2009Article
- Interdependence of laminin-mediated clustering of lipid rafts and the dystrophin complex in astrocytes.The Journal of biological chemistry · 2009Article
- Disturbances in PP2A methylation and one-carbon metabolism compromise Fyn distribution, neuritogenesis, and APP regulation.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Overexpression or clustering of the transmembrane form of the extracellular matrix heparan sulfate proteoglycan agrin (TM-agrin) induces the formation of highly dynamic filopodia-like processes on axons and dendrites from central and peripheral nervous system-derived neurons. Here we show that the formation of these processes is paralleled by a partitioning of TM-agrin into lipid rafts, that lipid rafts and transmembrane-agrin colocalize on the processes, that extraction of lipid rafts with methyl-beta-cyclodextrin leads to a dose-dependent reduction of process formation, that inhibition of lipid raft synthesis prevents process formation, and that the continuous presence of lipid rafts is required for the maintenance of the processes. Association of TM-agrin with lipid rafts results in the phosphorylation and activation of the Src family kinase Fyn and subsequently in the phosphorylation and activation of MAPK. Inhibition of Fyn or MAPK activation inhibits process formation. These results demonstrate that the formation of filopodia-like processes by TM-agrin is the result of the activation of a complex intracellular signaling cascade, supporting the hypothesis that TM-agrin is a receptor or coreceptor on neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.