ArticleGenome research2009
The mitochondrial genome sequence of the Tasmanian tiger (Thylacinus cynocephalus).
Article in Genome research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50 citing papers in PubMed, 127 citations in OpenAlex.
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- Illuminating the mystery of thylacine extinction: a role for relaxed selection and gene loss.Proceedings. Biological sciences · 2025Article
- Mitogenomic phylogeny and divergence time estimation of Artemia Leach, 1819 (Branchiopoda: Anostraca) with emphasis on parthenogenetic lineages.BMC genomics · 2025Article
- Aberrant Mitochondrial tRNA Genes Appear Frequently in Animal Evolution.Genome biology and evolution · 2024Article
- Karyotypic stasis and swarming influenced the evolution of viral tolerance in a species-rich bat radiation.Cell genomics · 2024Article
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- Clade-specific forebrain cytoarchitectures of the extinct Tasmanian tiger.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Historical RNA expression profiles from the extinct Tasmanian tiger.Genome research · 2023Article
- A Chromosome-Scale Hybrid Genome Assembly of the Extinct Tasmanian Tiger (Thylacinus cynocephalus).Genome biology and evolution · 2022Article
- Functional ecological convergence between the thylacine and small prey-focused canids.BMC ecology and evolution · 2021Article
- Uncovering the genomic and metagenomic research potential in old ethanol-preserved snakes.PloS one · 2021Article
- Digging into the Genomic Past of Swiss Honey Bees by Whole-Genome Sequencing Museum Specimens.Genome biology and evolution · 2020Article
- Museomics of tree squirrels: a dense taxon sampling of mitogenomes reveals hidden diversity, phenotypic convergence, and the need of a taxonomic overhaul.BMC evolutionary biology · 2020Article
- Advantages of an easy-to-use DNA extraction method for minimal-destructive analysis of collection specimens.PloS one · 2020Article
- Complete mitochondrial genome of a kind of snakehead fish Channa siamensis and its phylogenetic consideration.Genes & genomics · 2019Article
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- Total evidence phylogeny and evolutionary timescale for Australian faunivorous marsupials (Dasyuromorphia).BMC evolutionary biology · 2017Article
Corrections and comments
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Authors and funding
20 authors at 9 institutions in 6 countries.
Funding
Abstract
We report the first two complete mitochondrial genome sequences of the thylacine (Thylacinus cynocephalus), or so-called Tasmanian tiger, extinct since 1936. The thylacine's phylogenetic position within australidelphian marsupials has long been debated, and here we provide strong support for the thylacine's basal position in Dasyuromorphia, aided by mitochondrial genome sequence that we generated from the extant numbat (Myrmecobius fasciatus). Surprisingly, both of our thylacine sequences differ by 11%-15% from putative thylacine mitochondrial genes in GenBank, with one of our samples originating from a direct offspring of the previously sequenced individual. Our data sample each mitochondrial nucleotide an average of 50 times, thereby providing the first high-fidelity reference sequence for thylacine population genetics. Our two sequences differ in only five nucleotides out of 15,452, hinting at a very low genetic diversity shortly before extinction. Despite the samples' heavy contamination with bacterial and human DNA and their temperate storage history, we estimate that as much as one-third of the total DNA in each sample is from the thylacine. The microbial content of the two thylacine samples was subjected to metagenomic analysis, and showed striking differences between a wild-captured individual and a born-in-captivity one. This study therefore adds to the growing evidence that extensive sequencing of museum collections is both feasible and desirable, and can yield complete genomes.
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