ArticleNucleic acids research2009
Genome-wide analysis to predict protein sequence variations that change phosphorylation sites or their corresponding kinases.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Learning the PTM code through a coarse-to-fine mechanism-aware framework.Nature communications · 2026Article
- Decoding the genetic landscape of juvenile dermatomyositis: insights from phosphorylation-associated single nucleotide polymorphisms.Immunogenetics · 2024Article
- Post-translational modification prediction via prompt-based fine-tuning of a GPT-2 model.Nature communications · 2024Article
- RMDisease V2.0: an updated database of genetic variants that affect RNA modifications with disease and trait implication.Nucleic acids research · 2023Article
- Prediction of protein-ligand binding affinity from sequencing data with interpretable machine learning.Nature biotechnology · 2022Article
- PhosVarDeep: deep-learning based prediction of phospho-variants using sequence information.PeerJ · 2022Article
- RMDisease: a database of genetic variants that affect RNA modifications, with implications for epitranscriptome pathogenesis.Nucleic acids research · 2021Article
- Protein Phosphorylation Response to Abiotic Stress in Plants.Methods in molecular biology (Clifton, N.J.) · 2021Review
- KSP: an integrated method for predicting catalyzing kinases of phosphorylation sites in proteins.BMC genomics · 2020Article
- SNPs rs10224002 in PRKAG2 may disturb gene expression and consequently affect hypertension.Molecular biology reports · 2019Article
- Conservation of kinase-phosphorylation site pairings: Evidence for an evolutionarily dynamic phosphoproteome.PloS one · 2018Article
- Methods, Tools and Current Perspectives in Proteogenomics.Molecular & cellular proteomics : MCP · 2017Review
- Gender-Specific Associations between CHGB Genetic Variants and Schizophrenia in a Korean Population.Yonsei medical journal · 2017Article
- Mutation-Structure-Function Relationship Based Integrated Strategy Reveals the Potential Impact of Deleterious Missense Mutations in Autophagy Related Proteins on Hepatocellular Carcinoma (HCC): A Comprehensive Informatics Approach.International journal of molecular sciences · 2017Article
- Impact of SNPs on Protein Phosphorylation Status in Rice (Oryza sativa L.).International journal of molecular sciences · 2016Article
- Rewiring MAP kinases in Saccharomyces cerevisiae to regulate novel targets through ubiquitination.eLife · 2016Article
- Parkinson-Related LRRK2 Mutation R1628P Enables Cdk5 Phosphorylation of LRRK2 and Upregulates Its Kinase Activity.PloS one · 2016Article
- Systematic Analysis of the Genetic Variability That Impacts SUMO Conjugation and Their Involvement in Human Diseases.Scientific reports · 2015Article
- MIMP: predicting the impact of mutations on kinase-substrate phosphorylation.Nature methods · 2015Article
- A Comparative Analysis and Review of lysyl Residues Affected by Posttranslational Modifications.Current genomics · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We define phosphovariants as genetic variations that change phosphorylation sites or their interacting kinases. Considering the essential role of phosphorylation in protein functions, it is highly likely that phosphovariants change protein functions. Therefore, a comparison of phosphovariants between individuals or between species can give clues about phenotypic differences. We categorized phosphovariants into three subtypes and developed a system that predicts them. Our method can be used to screen important polymorphisms and help to identify the mechanisms of genetic diseases.
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