ArticleCancer prevention research (Philadelphia, Pa.)2008
Multiple aberrations of chromosome 3p detected in oral premalignant lesions.
Article in Cancer prevention research (Philadelphia, Pa.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 47 citations in OpenAlex.
- Genetic alterations and clinical dimensions of oral cancer: a review.Molecular biology reports · 2020Review
- DNA aneuploidy and tissue architecture in oral potentially malignant disorders with epithelial dysplasia assessed by a 10 locus FISH panel.Oncology reports · 2020Article
- Insights Into Lung Cancer Immune-Based Biology, Prevention, and Treatment.Frontiers in immunology · 2020Review
- Chromosomal Alterations and Gene Expression Changes Associated with the Progression of Leukoplakia to Advanced Gingivobuccal Cancer.Translational oncology · 2017Article
- Emerging role of sphingosine-1-phosphate signaling in head and neck squamous cell carcinoma.OncoTargets and therapy · 2016Review
- Recurring DNA copy number gain at chromosome 9p13 plays a role in the activation of multiple candidate oncogenes in progressing oral premalignant lesions.Cancer medicine · 2014Article
- Recurrent genomic alterations in sequential progressive leukoplakia and oral cancer: drivers of oral tumorigenesis?Human molecular genetics · 2014Article
- Chromosomal imbalances exclusively detected in invasive front area are associated with poor outcome in laryngeal carcinomas from different anatomical sites.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- Whole transcriptome sequencing identifies tumor-specific mutations in human oral squamous cell carcinoma.BMC medical genomics · 2013Article
- The identification of significant chromosomal regions correlated with oral tongue cancer progression.Journal of cancer research and clinical oncology · 2012Article
- Validation of LOH profiles for assessing oral cancer risk.Cancer prevention research (Philadelphia, Pa.) · 2012Article
- Peripheral T-lymphocytes express WNT7A and its restoration in leukemia-derived lymphoblasts inhibits cell proliferation.BMC cancer · 2012Article
- Toll-like receptor 2 is present in the microenvironment of oral squamous cell carcinoma.British journal of cancer · 2011Article
- Deciphering squamous cell carcinoma using multidimensional genomic approaches.Journal of skin cancer · 2011Article
- Integrative molecular characterization of head and neck cancer cell model genomes.Head & neck · 2010Article
- Multiple pathways in the FGF signaling network are frequently deregulated by gene amplification in oral dysplasias.International journal of cancer · 2009Article
- A dynamic oral cancer field: unraveling the underlying biology and its clinical implication.The American journal of surgical pathology · 2009Article
- Genomic imbalances in precancerous tissues signal oral cancer risk.Molecular cancer · 2009Article
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5 authors at 1 institution in 1 country.
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Abstract
The study of oral premalignant lesions (OPL) is crucial to the identification of initiating genetic events in oral cancer. However, these lesions are minute in size, making it a challenge to recover sufficient DNA from microdissected cells for comprehensive genomic analysis. As a step toward identifying genetic aberrations associated with oral cancer progression, we used tiling-path array comparative genomic hybridization to compare alterations on chromosome 3p for 71 OPLs against 23 oral squamous cell carcinomas. 3p was chosen because although it is frequently altered in oral cancers and has been associated with progression risk, its alteration status has only been evaluated at a small number of loci in OPLs. We identified six recurrent losses in this region that were shared between high-grade dysplasias and oral squamous cell carcinomas, including a 2.89-Mbp deletion spanning the FHIT gene (previously implicated in oral cancer progression). When the alteration status for these six regions was examined in 24 low-grade dysplasias with known progression outcome, we observed that they occurred at a significantly higher frequency in low-grade dysplasias that later progressed to later-stage disease (P < 0.003). Moreover, parallel analysis of all profiled tissues showed that the extent of overall genomic alteration at 3p increased with histologic stage. This first high-resolution analysis of chromosome arm 3p in OPLs represents a significant step toward predicting progression risk in early preinvasive disease and provides a keen example of how genomic instability escalates with progression to invasive cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.