ArticleCancer prevention research (Philadelphia, Pa.)2008
Single nucleotide polymorphism-based genome-wide chromosome copy change, loss of heterozygosity, and aneuploidy in Barrett's esophagus neoplastic progression.
Article in Cancer prevention research (Philadelphia, Pa.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 77 citations in OpenAlex.
- Molecular Pathology of Gastroesophageal Cancer.Clinics in laboratory medicine · 2024Review
- Molecular characterization of Barrett's esophagus at single-cell resolution.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Alteration of protein expression and spliceosome pathway activity during Barrett's carcinogenesis.Journal of gastroenterology · 2021Article
- Molecular Pathology of Gastroesophageal Cancer.Surgical pathology clinics · 2021Review
- DNA methylation markers in esophageal cancer: an emerging tool for cancer surveillance and treatment.American journal of cancer research · 2021Review
- Genomic landscape of allelic imbalance in premalignant atypical adenomatous hyperplasias of the lung.EBioMedicine · 2019Article
- Article
- A biomarker panel predicts progression of Barrett's esophagus to esophageal adenocarcinoma.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2019Article
- Evolution of Barrett's esophagus through space and time at single-crypt and whole-biopsy levels.Nature communications · 2018Article
- Whole slide image cytometry: a novel method to detect abnormal DNA content in Barrett's esophagus.Laboratory investigation; a journal of technical methods and pathology · 2015Article
- Genetic Insights in Barrett's Esophagus and Esophageal Adenocarcinoma.Gastroenterology · 2015Review
- Assessment of Esophageal Adenocarcinoma Risk Using Somatic Chromosome Alterations in Longitudinal Samples in Barrett's Esophagus.Cancer prevention research (Philadelphia, Pa.) · 2015Article
- Paired exome analysis of Barrett's esophagus and adenocarcinoma.Nature genetics · 2015Article
- Biomarkers of Barrett's esophagus.World journal of gastrointestinal pathophysiology · 2014Review
- Comparison of cancer-associated genetic abnormalities in columnar-lined esophagus tissues with and without goblet cells.Annals of surgery · 2014Article
- Next-generation sequencing of endoscopic biopsies identifies ARID1A as a tumor-suppressor gene in Barrett's esophagus.Oncogene · 2014Article
- Temporal and spatial evolution of somatic chromosomal alterations: a case-cohort study of Barrett's esophagus.Cancer prevention research (Philadelphia, Pa.) · 2014Article
- Predictive biomarkers for Barrett's esophagus: so near and yet so far.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2013Review
- NSAIDs modulate clonal evolution in Barrett's esophagus.PLoS genetics · 2013Article
- GERD-Barrett-Adenocarcinoma: Do We Have Suitable Prognostic and Predictive Molecular Markers?Gastroenterology research and practice · 2013Article
Corrections and comments
- Commented on by
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Chromosome copy gain, loss, and loss of heterozygosity (LOH) involving most chromosomes have been reported in many cancers; however, less is known about chromosome instability in premalignant conditions. 17p LOH and DNA content abnormalities have been previously reported to predict progression from Barrett's esophagus (BE) to esophageal adenocarcinoma (EA). Here, we evaluated genome-wide chromosomal instability in multiple stages of BE and EA in whole biopsies. Forty-two patients were selected to represent different stages of progression from BE to EA. Whole BE or EA biopsies were minced, and aliquots were processed for flow cytometry and genotyped with a paired constitutive control for each patient using 33,423 single nucleotide polymorphisms (SNP). Copy gains, losses, and LOH increased in frequency and size between early- and late-stage BE (P < 0.001), with SNP abnormalities increasing from <2% to >30% in early and late stages, respectively. A set of statistically significant events was unique to either early or late, or both, stages, including previously reported and novel abnormalities. The total number of SNP alterations was highly correlated with DNA content aneuploidy and was sensitive and specific to identify patients with concurrent EA (empirical receiver operating characteristic area under the curve = 0.91). With the exception of 9p LOH, most copy gains, losses, and LOH detected in early stages of BE were smaller than those detected in later stages, and few chromosomal events were common in all stages of progression. Measures of chromosomal instability can be quantified in whole biopsies using SNP-based genotyping and have potential to be an integrated platform for cancer risk stratification in BE.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.