ReviewPulmonary pharmacology & therapeutics2009
Cough and gastroesophageal reflux: insights from animal models.
Review in Pulmonary pharmacology & therapeutics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 49 citations in OpenAlex.
- Well-Established and Traditional Use of Vegetal Extracts as an Approach to the "Deep Roots" of Cough.Children (Basel, Switzerland) · 2024Review
- Diagnostic value of reflux episodes in gastroesophageal reflux-induced chronic cough: a novel predictive indicator.Therapeutic advances in chronic disease · 2022Article
- Cough as a Cause and Consequence of Heart Dysfunction - Current State of Art.Physiological research · 2020Review
- The Prospect for Potent Sodium Voltage-Gated Channel Blockers to Relieve an Excessive Cough.Physiological research · 2020Review
- Clinical Practice Guidelines for Diagnosis and Management of Cough-Chinese Thoracic Society (CTS) Asthma Consortium.Journal of thoracic disease · 2018Review
- Dorsal Vagal Complex Modulates Neurogenic Airway Inflammation in a Guinea Pig Model With Esophageal Perfusion of HCl.Frontiers in physiology · 2018Article
- Peripheral neural circuitry in cough.Current opinion in pharmacology · 2015Review
- What is chronic cough in children?Frontiers in physiology · 2014Review
- Detection of mouse cough based on sound monitoring and respiratory airflow waveforms.PloS one · 2013Article
- The transient receptor potential channel TRPA1: from gene to pathophysiology.Pflugers Archiv : European journal of physiology · 2012Review
- Article
- Gastroesophageal reflux disease and atrial fibrillation: a nationwide population-based study.PloS one · 2012Article
- Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system.Pharmacology & therapeutics · 2011Review
- Dilated intercellular spaces and chronic cough as an extra-oesophageal manifestation of gastrooesophageal reflux disease.Pulmonary pharmacology & therapeutics · 2011Article
- TRP channels in the digestive system.Current pharmaceutical biotechnology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Chronic cough in gastroesophageal reflux disease (GERD) has been attributed to irritation of the esophagus and/or upper airways by reflux of gastric content. Animal models have provided insight into both of these putative mechanisms. In patients with chronic cough and GERD, stimuli associated with reflex in the esophagus sensitize the cough reflex. This sensitization can be reproduced in the guinea pig and is most likely mediated by the esophageal afferent nerve fibers carried by the vagus nerves. Studies in animals have identified several subtypes of vagal esophageal C-fibers that may subserve this function. The putative nociceptive vagal C-fibers in the guinea pig esophagus are stimulated by acid and express the TRPV1 and TRPA1 receptors that confer responsiveness to disparate noxious stimuli. Acute and/or chronic irritation of the upper airways by reflux may contribute to cough by stimulation and/or sensitization of the airway afferent nerves. Studies in animals have identified airway nerves that likely initiate cough due to aspirated reflux; have characterized their pharmacology; and have provided insight into changes of their sensitivity. Studies in animal models have also described the neurophysiology of reflexes that protect the airways from reflux. In conclusion, animal models provide mechanistic insight into the modulation of cough from the esophagus and the pharmacology of neural pathways mediating cough in GERD.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.