ArticleWorld journal of surgical oncology2009
Perioperative immune responses in cancer patients undergoing digestive surgeries.
Article in World journal of surgical oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Comparison of postoperative lymphocytes and interleukins between laparoscopy-assisted and open radical gastrectomy for early gastric cancer.The Journal of international medical research · 2019Trial
- Trial
- The postoperative platelet-to-lymphocyte ratio predicts the outcome of patients undergoing pancreaticoduodenectomy for pancreatic head cancer.Surgery today · 2024Article
- Risk factors for unplanned intensive care unit admission after esophagectomy: a retrospective cohort study of 628 patients with esophageal cancer.Frontiers in oncology · 2024Article
- Anesthesia and cancer recurrence: an overview.Journal of anesthesia, analgesia and critical care · 2022Review
- Blood transfusion had no influence on the 5-year biochemical recurrence after robot-assisted radical prostatectomy: a retrospective study.BMC urology · 2021Article
- Long-term survival differences between sevoflurane and propofol use in general anesthesia for gynecologic cancer surgery.Journal of anesthesia · 2021Article
- Effect of ligustrazine nanoparticles on Th1/Th2 balance by TLR4/MyD88/NF-κB pathway in rats with postoperative peritoneal adhesion.BMC surgery · 2021Article
- Preoperative lymphocyte-to-monocyte ratio predicts postoperative infectious complications after laparoscopic colorectal cancer surgery.International journal of clinical oncology · 2020Article
- Immune reaction by cytoreductive prostatectomy.American journal of clinical and experimental urology · 2019Review
- Observational
- Malignancy is a risk factor for postoperative infectious complications after elective colorectal resection.International journal of colorectal disease · 2016Article
- Surgical Stress Abrogates Pre-Existing Protective T Cell Mediated Anti-Tumor Immunity Leading to Postoperative Cancer Recurrence.PloS one · 2016Article
- Evaluation of immune responses of gastric cancer patients treated by laparoscopic and open gastrectomy.Medical oncology (Northwood, London, England) · 2015Article
- Regulating surgical oncotaxis to improve the outcomes in cancer patients.Surgery today · 2014Review
- The immune response to surgery and infection.Central-European journal of immunology · 2014Review
- Nutritional Effect of Oral Supplement Enriched in ω-3 Fatty Acids, Arginine, RNA on Immune Response and Leukocyte-platelet Aggregate Formation in Patients Undergoing Cardiac Surgery.Nutrition and metabolic insights · 2014Article
- CCR3, CCR4, CCR5, and CXCR3 expression in peripheral blood CD4+ lymphocytes in gastric cancer patients.Advanced biomedical research · 2013Article
- Alterations of dendritic cell subsets and TH1/TH2 cytokines in the peripheral circulation of patients with superficial transitional cell carcinoma of the bladder.Journal of clinical laboratory analysis · 2012Article
- Effect of Acute Surgical Stress on Serum Ghrelin Levels.Gastroenterology research · 2012Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTh1/Th2 cell balance is thought to be shifted toward a Th2-type immune response not only by malignancy but also by surgical stress. The aim of this study was to estimate perioperative immune responses with respect to the Th1/Th2 balance in patients with gastrointestinal cancer.
methodsNinety-four patients who underwent abdominal surgeries were divided into three groups: gastric resection (n = 40), colorectal resection (n = 34) and hepatic resection (n = 20). Twelve patients undergoing laparoscopic cholecystectomy and 20 healthy subjects were served as control groups. Intracellular cytokine staining in CD4+ T lymphocytes was identified to characterize Th1/Th2 balance. Th1/Th2 balance was evaluated before operation and until postoperative days (POD) 14.
resultsThe preoperative Th1/Th2 ratio was significantly lower in patients with malignancy compared with control. The Th1/Th2 ratio of patients in all groups decreased significantly postoperatively. Th1/Th2 balance on POD 2 in patients with malignancy was significantly decreased compared to patients with laparoscopic cholecystectomy, but there were no significant differences among the four groups on POD 14.
conclusionPatients with malignancy showed an abnormal perioperative Th1/Th2 balance suggesting predominance of a type-2 immune response. Major abdominal surgeries induce a marked shift in Th1/Th2 balance toward Th2 in the early postoperative stage.
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