ArticleRadiation research2009
Thyroid nodules, polymorphic variants in DNA repair and RET-related genes, and interaction with ionizing radiation exposure from nuclear tests in Kazakhstan.
Article in Radiation research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 5 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 5 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- XRCC1 Arg194Trp polymorphism and thyroid cancer.Journal of endocrinological investigation · 2020Pooled it
- Association between the XRCC1 Arg194Trp polymorphism and risk of cancer: evidence from 201 case-control studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Association of XRCC1 polymorphisms with thyroid cancer risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Association between the XRCC1 polymorphisms and thyroid cancer risk: a meta-analysis from case-control studies.PloS one · 2014Pooled it
- XRCC1 gene polymorphisms and the risk of differentiated thyroid carcinoma (DTC): a meta-analysis of case-control studies.PloS one · 2013Pooled it
- Review
- Polymorphisms of DNA Repair Genes in Thyroid Cancer.International journal of molecular sciences · 2024Review
- Genetic markers of cardiac autonomic neuropathy in the Kazakh population.BMC cardiovascular disorders · 2024Article
- Clinical utility ofArchives of endocrinology and metabolism · 2021Article
- GA Genotype of the Arg280His Polymorphism on TheBalkan journal of medical genetics : BJMG · 2021Article
- The State Scientific Automated Medical Registry, Kazakhstan: an important resource for low-dose radiation health research.Radiation and environmental biophysics · 2019Review
- Genetic Association of XRCC1 Gene rs1799782, rs25487 and rs25489 Polymorphisms with Risk of Thyroid Cancer: a Systematic Review and Meta-AnalysisAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Polymorphisms in selected DNA repair genes and cell cycle regulating genes involved in the risk of papillary thyroid carcinoma.Cancer biomarkers : section A of Disease markers · 2016Article
- Personalized Cancer Risk Assessments for Space Radiation Exposures.Frontiers in oncology · 2016Review
- Accounting for shared and unshared dosimetric uncertainties in the dose response for ultrasound-detected thyroid nodules after exposure to radioactive fallout.Radiation research · 2015Article
- Association between XRCC1 and XRCC3 gene polymorphisms and risk of thyroid cancer.International journal of clinical and experimental pathology · 2015Article
- Neuroendocrine Merkel cell carcinoma is associated with mutations in key DNA repair, epigenetic and apoptosis pathways: a case-based study using targeted massively parallel sequencing.Neuroendocrinology · 2015Article
- Article
- First survey of the two polymorphisms (Arg194Trp and Arg399Gln) in XRCC1 gene in four Afghanistan populations and comparison with worldwide data.Molecular biology reports · 2013Article
- Second malignant neoplasms and cardiovascular disease following radiotherapy.Journal of the National Cancer Institute · 2012Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
Abstract
Risk factors for thyroid cancer remain largely unknown except for ionizing radiation exposure during childhood and a history of benign thyroid nodules. Because thyroid nodules are more common than thyroid cancers and are associated with thyroid cancer risk, we evaluated several polymorphisms potentially relevant to thyroid tumors and assessed interaction with ionizing radiation exposure to the thyroid gland. Thyroid nodules were detected in 1998 by ultrasound screening of 2997 persons who lived near the Semipalatinsk nuclear test site in Kazakhstan when they were children (1949-1962). Cases with thyroid nodules (n = 907) were frequency matched (1:1) to those without nodules by ethnicity (Kazakh or Russian), gender and age at screening. Thyroid gland radiation doses were estimated from fallout deposition patterns, residence history and diet. We analyzed 23 polymorphisms in 13 genes and assessed interaction with ionizing radiation exposure using likelihood ratio tests (LRT). Elevated thyroid nodule risks were associated with the minor alleles of RET S836S (rs1800862, P = 0.03) and GFRA1 -193C>G (rs not assigned, P = 0.05) and decreased risk with XRCC1 R194W (rs1799782, P trend = 0.03) and TGFB1 T263I (rs1800472, P = 0.009). Similar patterns of association were observed for a small number of papillary thyroid cancers (n = 25). Ionizing radiation exposure to the thyroid gland was associated with significantly increased risk of thyroid nodules (age and gender adjusted excess odds ratio/Gy = 0.30, 95% CI 0.05-0.56), with evidence for interaction by genotype found for XRCC1 R194W (LRT P value = 0.02). Polymorphisms in RET signaling, DNA repair and proliferation genes may be related to risk of thyroid nodules, consistent with some previous reports on thyroid cancer. Borderline support for gene-radiation interaction was found for a variant in XRCC1, a key base excision repair protein. Other pathways such as genes in double-strand break repair, apoptosis and genes related to proliferation should also be pursued.
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