Evidence map›Paper›PMID 1913779›Full record

ArticleCell and tissue research1991

Pituitary adenylate cyclase-activating peptide (PACAP), a new vasoactive intestinal peptide (VIP)-like peptide in the respiratory tract.

R Uddman, A Luts, A Arimura, F Sundler

Abstract read
PubMed Publisher
In one paragraph

Article in Cell and tissue research, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 121 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Protective effects of PACAP in ischemia.The journal of headache and pain · 2018
    Review
  5. PACAP38 in human models of primary headaches.The journal of headache and pain · 2017
    Review
  6. Pituitary adenylate cyclase-activating peptide receptor 1 mediates anti-inflammatory effects in allergic airway inflammation in mice.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2011
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. In vivo restitution of airway epithelium.Cell and tissue research · 1995
    Article
  13. Molecular cloning and functional expression of the pituitary adenylate cyclase-activating polypeptide type I receptor.Proceedings of the National Academy of Sciences of the United States of America · 1993
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

R UddmanDepartment of Otorhinolaryngology, Malmö General Hospital, Sweden.
A Luts
A Arimura
F Sundler
Lund University · SEBiomedical Research Laboratories (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pituitary adenylate cyclase-activating peptide (PACAP) is a vasoactive intestinal peptide (VIP)-like peptide recently isolated from ovine hypothalami. Nerve fibers displaying PACAP immunoreactivity were found in the respiratory tract of rats, guinea pigs, ferrets, pigs, sheep and squirrel monkeys. A moderate supply of PACAP-immunoreactive fibers was seen in the nasal mucosa of guinea pigs. Few to moderate numbers of PACAP-containing fibers occurred in the tracheo-bronchial wall of rats, guinea pigs, ferrets, pigs, sheep and squirrel monkeys. The fibers were distributed beneath the epithelium, around blood vessels and seromucous glands, and among bundles of smooth muscle. In the lungs, the immunoreactive fibers were observed close to small bronchioli. A few PACAP-immunoreactive nerve cell bodies were seen in the sphenopalatine and otic ganglia of guinea pigs. Simultaneous double immunostaining of the respiratory tract of sheep and ferrets revealed that all PACAP-containing nerve fibers stored VIP. We suggest that neuronal PACAP may take part in the regulation of smooth muscle tone and glandular secretion.

Indexed as

AnimalsBronchiFerretsFluorescent Antibody TechniqueGuinea PigsImmune SeraImmunohistochemistryLungNasal MucosaNerve FibersNeuropeptidesPituitary Adenylate Cyclase-Activating PolypeptideRatsRespiratory SystemSaimiriSheepAdcyap1 protein, ratImmune SeraNeuropeptidesPituitary Adenylate Cyclase-Activating PolypeptideVasoactive Intestinal Peptide

Identifiers

PMID1913779
OpenAlexW2004129966

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.