ArticleCell and tissue research1991
Morphological evidence for a close interaction of chromaffin cells with cortical cells within the adrenal gland.
Article in Cell and tissue research, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 116 citations in OpenAlex.
- High-Resolution 3D reconstruction and visualization of normal adrenal vasculature and sympathetic nerves in mice.Endocrine · 2026Article
- Serotonin and the serotonin transporter in the adrenal gland.Vitamins and hormones · 2024Review
- Consequences of spinal cord injury on the sympathetic nervous system.Frontiers in cellular neuroscience · 2023Review
- The Enigma of the Adrenarche: Identifying the Early Life Mechanisms and Possible Role in Postnatal Brain Development.International journal of molecular sciences · 2021Review
- The Hypothalamic-Pituitary-Adrenal Axis: Development, Programming Actions of Hormones, and Maternal-Fetal Interactions.Frontiers in behavioral neuroscience · 2020Review
- Vitamin D3 May Ameliorate the Ketoconazole Induced Adrenal Injury: Histological and Immunohistochemical Studies on Albino Rats.Acta histochemica et cytochemica · 2015Article
- Chromaffin progenitor cells from the adrenal medulla.Cellular and molecular neurobiology · 2010Article
- Revisiting the stimulus-secretion coupling in the adrenal medulla: role of gap junction-mediated intercellular communication.Molecular neurobiology · 2009Review
- Age-dependent regulation of chromaffin cell proliferation by growth factors, dehydroepiandrosterone (DHEA), and DHEA sulfate.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Association of adrenal medullar and cortical nodular hyperplasia: a report of two cases with clinical and morpho-functional considerations.Endocrine · 2006Article
- Cortical-chromaffin cell interactions in the adrenal gland.Endocrine pathology · 2005Review
- Annual variations of adrenal gland hormones in the lizard Podarcis sicula.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2004Article
- Role of neurotransmitters and neuropeptides in the regulation of the adrenal cortex.Reviews in endocrine & metabolic disorders · 2001Review
- Applications of immunogold and lectin-gold labeling in tumor research and diagnosis.Histochemistry and cell biology · 1996Review
- Zone-specific localization of cytochrome P45011B1 in human adrenal tissue by PCR-derived riboprobes.Histochemistry and cell biology · 1995Article
- Distribution and colocalization of nitric oxide synthase and NADPH-diaphorase in adrenal gland of developing, adult and aging Sprague-Dawley rats.Cell and tissue research · 1994Article
- Autonomic control of adrenal function.Journal of anatomy · 1993Review
- Evidence that an extrahypothalamic pituitary corticotropin-releasing hormone (CRH)/adrenocorticotropin (ACTH) system controls adrenal growth and secretion in rats.Cell and tissue research · 1993Article
- Expression and localization of intestinal 15 kDa protein in the rat.Molecular and cellular biochemistryArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adrenal medulla appears to exert a regulatory influence on adrenocortical steroidogenesis. We have therefore studied the morphology of rat, porcine and bovine adrenals in order to characterize the contact zones of adrenomedullary and adrenocortical tissues. The distribution of chromaffin cells located within the adrenal cortex and of cortical cells located within the adrenal medulla was investigated. Chromaffin cells were characterized by immunostaining for synaptophysin and chromogranin A, both being considered specific for neuroendocrine cells. Cortical cells were characterized by immunostaining for 17 alpha-hydroxylase, an enzyme of the steroid pathway. Cellular contacts of chromaffin cells and cortical cells were examined at the electron microscopical level. In rat and porcine adrenals, rays of chromaffin cells, small cell clusters and single chromaffin cells or small invaginations from the medulla could be detected in all three zones of the cortex. Chromaffin cells often spread in the subcapsular space of the zona glomerulosa. In porcine and bovine adrenals, 17 alpha-hydroxylase immunoreactive cells were localized within the medulla. Single cortical cells and small accumulations of cells were spread throughout this region. At the ultrastructural level, the chromaffin cells located within the cortex in pig and rat adrenals formed close cellular contacts with cortical cells in all three zones. Our morphological data provide evidence for a possible paracrine role of chromaffin cells; this may be important for the neuroregulation of the adrenal cortex.
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