ArticleInternational urology and nephrology2009
Performance of the Cockcroft-Gault and MDRD equations in adult Nigerians with chronic kidney disease.
Article in International urology and nephrology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and burden of chronic kidney disease among the general population and high-risk groups in Africa: a systematic review.BMJ open · 2018Pooled it
- Article
- Article
- The prevalence of chronic kidney disease in apparently healthy retired subjects in asaba, Nigeria.Annals of medical and health sciences research · 2014Article
- Simple assessment of patient's stage of chronic kidney disease using eGFR-MDRD nomograms.International urology and nephrology · 2012Article
- A comparison of different methods for the determination of glomerular filtration rate in elderly patients with chronic renal failure.International urology and nephrology · 2011Article
- Glomerular filtration rate (GFR) estimated from serum creatinine predicts total (urine and peritoneal) creatinine clearance in patients on peritoneal dialysis.International urology and nephrology · 2010Article
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Authors and funding
4 authors.
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Abstract
backgroundEstimation of the glomerular filtration rate (GFR) is required in the assessment of patients with chronic kidney disease (CKD) in order to provide information regarding the functional status of the kidneys. Current guidelines advocate the use of prediction equations, such as the Cockcroft-Gault (CG) formula and the Modification of Diet in Renal Disease (MDRD) study-derived equations, over clearance of endogenous creatinine (Ccr) in achieving this aim. We were interested in knowing the accuracy of these equations in predicting the GFR in adult Nigerians with CKD.
methodsWe conducted a review of records of patients who were evaluated for CKD at the Nephrology Clinic of the Jos University Teaching Hospital between 2001 and 2003. We compared the CG and MDRD equations against the Ccr in predicting the GFR in 130 patients (88 males and 42 females) with CKD.
resultsThe means +/- standard deviation (SD) for the measured and predicted GFR by the CG and MDRD equations were similar (17.6 +/- 25.8 ml/min, 19.9 +/- 24.0 ml/min and 21.5 +/- 28.2 ml/min, respectively; analysis of variance [ANOVA], F = 0.68, P = 0.5). The mean difference between CG and Ccr was -2.2 +/- 14.8 ml/min, with discordance at Ccr values >25 ml/min. The mean difference between MDRD and Ccr was -3.9 +/- 18.1 ml/min, with discordance at Ccr values >40 ml/min.
conclusionThe CG and MDRD equations provide reliable alternatives to measured Ccr in the estimation of the GFR in Nigerian patients with CKD.
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