ArticleJournal of industrial microbiology & biotechnology2009
Influence of growth conditions on the nisin production of bioengineered Lactococcus lactis strains.
Article in Journal of industrial microbiology & biotechnology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Bioengineering of a Lactococcus lactis subsp. lactis strain enhances nisin production and bioactivity.PloS one · 2023Article
- Application of Biotechnology in Specific Spoilage Organisms of Aquatic Products.Frontiers in bioengineering and biotechnology · 2022Review
- Engineering Lactococcus lactis as a multi-stress tolerant biosynthetic chassis by deleting the prophage-related fragment.Microbial cell factories · 2020Article
- NisI Maturation and Its Influence on Nisin Resistance in Lactococcus lactis.Applied and environmental microbiology · 2020Article
- Nisin Z Production by Wild Strains ofInternational journal of microbiology · 2020Article
- New bacitracin-resistant nisin-producing strain ofAIMS microbiology · 2018Article
- Enhance nisin yield via improving acid-tolerant capability of Lactococcus lactis F44.Scientific reports · 2016Article
- Nisin production in a chitin-including continuous fermentation system with Lactococcus lactis displaying a cell wall chitin-binding domain.Journal of industrial microbiology & biotechnology · 2014Article
- The Lcn972 bacteriocin-encoding plasmid pBL1 impairs cellobiose metabolism in Lactococcus lactis.Applied and environmental microbiology · 2011Article
- Continuous nisin production with bioengineered Lactococcus lactis strains.Journal of industrial microbiology & biotechnology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nisin production of three bioengineered strains, (LAC338, LAC339 and LAC340) with immunity (nisFEG) and/or regulation (nisRK) genes of nisin biosynthesis on plasmids in the Lactococcus lactis LL27 nisin producer, was evaluated under pH-controlled and pH-uncontrolled batch fermentations. Optimization studies showed that fructose and yeast extract yielded the highest nisin activity. The strains LAC338, LAC339, and LAC340 produced 24, 45, and 44% more nisin, respectively, than wild-type L. lactis LL27 after 12-h incubation. However, sharp decreases in the yield of nisin were observed at the late phase of fermentation with LAC339 and LL27 in contrast to LAC340 and LAC338 strains for which the high level of nisin could be maintained longer. Obviously, increasing the copy number of the regulation genes together with immunity genes in the nisin producers retarded the loss of nisin in the late phase of the fermentation.
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