ReviewInternational journal of obesity (2005)2008
Molecular physiology of weight regulation in mice and humans.
Review in International journal of obesity (2005), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed.
- Weight Change 2 Years After Termination of the Intensive Lifestyle Intervention in the Look AHEAD Study.Obesity (Silver Spring, Md.) · 2020Trial
- Carbohydrate modified diet & insulin sensitizers reduce body weight & modulate metabolic syndrome measures in EMPOWIR (enhance the metabolic profile of women with insulin resistance): a randomized trial of normoglycemic women with midlife weight gain.PloS one · 2014 · on this mapTrial
- Physical activity and the risk of becoming overweight or obese in middle-aged and older women.Obesity (Silver Spring, Md.) · 2012Trial
- Leptin reverses declines in satiation in weight-reduced obese humans.The American journal of clinical nutrition · 2012Trial
- Weight Loss Plateau: Reasons, Challenges, and Solutions: A Narrative Review.Health science reports · 2026Article
- Leishmanicidal Action of the Peptides 19-4LF, 19-2.5 and 19-2.5LF Topically Administered on Cutaneous Lesions Caused byPharmaceutics · 2026Article
- Interactions among nutrition, metabolism and the immune system in the context of starvation and nutrition-stimulated obesity.Nutrition & diabetes · 2025Review
- Medial hypothalamic MC3R signalling regulates energy rheostasis in adult mice.The Journal of physiology · 2025Article
- Investigating the Effect of Enterally Administered Capromorelin on Body Weight in Mice (Mus musculus).Comparative medicine · 2024Article
- Neuroanatomical dissection of the MC3R circuitry regulating energy rheostasis.bioRxiv : the preprint server for biology · 2024Article
- Changes of the Concentration of Short-Chain Fatty Acids in the Intestines of Mice with Different Types of Obesity.Bulletin of experimental biology and medicine · 2024Article
- Unveiling frailty: comprehensive and sex-specific characterization in prematurely aging PolgA mice.Frontiers in aging · 2024Article
- Finding balance: understanding the energetics of time-restricted feeding in mice.Obesity (Silver Spring, Md.) · 2023Review
- FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes.Scientific reports · 2022Article
- A novel nitroalkene vitamin E analogue inhibits the NLRP3 inflammasome and protects against inflammation and glucose intolerance triggered by obesity.Redox biology · 2021Article
- Urinary Excretion of Iohexol as a Permeability Marker in a Mouse Model of Intestinal Inflammation: Time Course, Performance and Welfare Considerations.Animals : an open access journal from MDPI · 2021Article
- Fat-On-A-Chip Models for Research and Discovery in Obesity and Its Metabolic Comorbidities.Tissue engineering. Part B, Reviews · 2020Review
- Body Mass Dynamics Is Determined by the Metabolic Ohm's Law and Adipocyte-Autonomous Fat Mass Homeostasis.iScience · 2020Article
- Knockout of the X-linkedFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice.Nature communications · 2019Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Evolutionary considerations relating to efficiency in reproduction, and survival in hostile environments, suggest that body energy stores are sensed and actively regulated, with stronger physiological and behavioral responses to loss than gain of stored energy. Many physiological studies support this inference, and suggest that a critical axis runs between body fat and the hypothalamus. The molecular cloning of leptin and its receptor-projects based explicitly on the search for elements in this axis-confirmed the existence of this axis and provided important tools with which to understand its molecular physiology. Demonstration of the importance of this soma-brain reciprocal connection in body weight regulation in humans has been pursued using both classical genetic approaches and studies of physiological responses to experimental weight perturbation. This paper reviews the history of the rationale and methodology of the cloning of leptin (Lep) and the leptin receptor (Lepr), and describes some of the clinical investigation characterizing this axis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.