ArticleNature genetics2009
Experimental evolution reveals natural selection on standing genetic variation.
Article in Nature genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
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Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide meta-analysis identified novel variant associated with hallux valgus in Caucasians.Journal of foot and ankle research · 2020Pooled it
- Intersecting experimental evolution and CRISPR screens to identify novel toxin resistance loci.eLife · 2026Article
- Additive effects of environmental and demographic variation shape the repeatability of evolution across replicated experiments.Evolution letters · 2026Article
- Differences among populations and changes during domestication in the lipidome of Queensland fruit fly.BMC ecology and evolution · 2025Article
- Genome-wide analyses reveal intricate genetic mechanisms underlying egg production efficiency in chickens.Journal of animal science and biotechnology · 2025Article
- Linking individual fitness to the evolution of cognition.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- An ancient origin of the naked grains of maize.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
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- Neutral drift upon threshold-like selection promotes variation in antibiotic resistance phenotype.Nature communications · 2024Article
- A Path Integral Approach for Allele Frequency Dynamics Under Polygenic Selection.bioRxiv : the preprint server for biology · 2024Article
- Genetic basis and repeatability for desiccation resistance in Drosophila melanogaster (Diptera: Drosophilidae).Genetica · 2024Article
- How predictable is adaptation from standing genetic variation? Experimental evolution inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Species dynamics in natural bacterial communities over multiple rounds of propagation.Evolutionary applications · 2022Article
- Hybrid evolution repeats itself across environmental contexts in Texas sunflowers (Helianthus).Evolution; international journal of organic evolution · 2022Article
- Mutation or not, what directly establishes a neoplastic state, namely cellular immortality and autonomy, still remains unknown and should be prioritized in our research.Journal of Cancer · 2022Review
- Return of the Lemnaceae: duckweed as a model plant system in the genomics and postgenomics era.The Plant cell · 2021Article
- Eco-Evolutionary Dynamics in Microbial Communities from Spontaneous Fermented Foods.International journal of environmental research and public health · 2021Article
- Resampling the pool of genotypic possibilities: an adaptive function of sexual reproduction.BMC ecology and evolution · 2021Article
- Polygenic adaptation: a unifying framework to understand positive selection.Nature reviews. Genetics · 2020Review
- Natural selection on sleep duration in Drosophila melanogaster.Scientific reports · 2020Article
17 more citing papers are in PubMed but not listed here.
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evolution depends on genetic variation generated by mutation or recombination from standing genetic variation. In sexual organisms, little is known about the molecular population genetics of adaptation and reverse evolution. We carry out 50 generations of experimental reverse evolution in populations of Drosophila melanogaster, previously differentiated by forward evolution, and follow changes in the frequency of SNPs in both arms of the third chromosome. We characterize the effects of sampling finite population sizes and natural selection at the genotype level. We demonstrate that selection has occurred at several loci and further that there is no general loss or gain of allele diversity. We also observe that despite the complete convergence to ancestral levels of adaptation, allele frequencies only show partial return.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.