ArticleJournal of bacteriology2009
African 1, an epidemiologically important clonal complex of Mycobacterium bovis dominant in Mali, Nigeria, Cameroon, and Chad.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed.
- First isolation of Mycobacterium tuberculosis from suspected cases of bovine tuberculosis in rural abattoirs in Chad.Tropical animal health and production · 2026Article
- Insight into the genetic diversity ofMicrobiology spectrum · 2026Article
- First report of whole genome sequence of a Mycobacterium bovis (3/86Rv) strain isolated from a cow in India.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Phylogenetic analysis of Mycobacterium bovis reveals animal and zoonotic tuberculosis spread between Morocco and European countries.PLoS neglected tropical diseases · 2025Article
- Enhanced analysis of the genomic diversity ofFrontiers in microbiology · 2025Article
- Zoonotic transmission of theFrontiers in veterinary science · 2025Article
- Genetic diversities and drug resistance in Mycobacterium bovis isolates from zoonotic tuberculosis using whole genome sequencing.BMC genomics · 2024Article
- Preliminary study of molecular identification of Mycobacterium bovis from cow's milk in Lorestan (Iran).Scientific reports · 2024Article
- First Insight into the Whole Genome Sequencing Whole Variations inMicroorganisms · 2024Article
- InsideFrontiers in microbiology · 2024Article
- Molecular Characterisation ofCurrent issues in molecular biology · 2023Article
- Bovine tuberculosis in India: The need for One Health approach and the way forward.One health (Amsterdam, Netherlands) · 2023Review
- Features ofMicroorganisms · 2023Article
- Prevalence and molecular characterization of Mycobacterium tuberculosis complex in cattle and humans, Maiduguri, Borno state, Nigeria: a cross-sectional study.BMC microbiology · 2023Article
- Unraveling the epidemiology ofFrontiers in veterinary science · 2023Article
- Spoligotype analysis ofZoonoses and public health · 2022Article
- Molecular epidemiology of bovine tuberculosis in Northern Ghana identifies several uncharacterized bovine spoligotypes and suggests possible zoonotic transmission.PLoS neglected tropical diseases · 2022Article
- Spatial distribution of Mycobacterium bovis spoligotypes in cattle from the state of Minas Gerais, Brazil.Tropical animal health and production · 2022Article
- Prevalence and Molecular Characterization ofMicroorganisms · 2022Article
- SITVITBovis-a publicly available database and mapping tool to get an improved overview of animal and human cases caused by Mycobacterium bovis.Database : the journal of biological databases and curation · 2022Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
34 authors.
Funding
Abstract
We have identified a clonal complex of Mycobacterium bovis present at high frequency in cattle in population samples from several sub-Saharan west-central African countries. This closely related group of bacteria is defined by a specific chromosomal deletion (RDAf1) and can be identified by the absence of spacer 30 in the standard spoligotype typing scheme. We have named this group of strains the African 1 (Af1) clonal complex and have defined the spoligotype signature of this clonal complex as being the same as the M. bovis BCG vaccine strain but with the deletion of spacer 30. Strains of the Af1 clonal complex were found at high frequency in population samples of M. bovis from cattle in Mali, Cameroon, Nigeria, and Chad, and using a combination of variable-number tandem repeat typing and spoligotyping, we show that the population of M. bovis in each of these countries is distinct, suggesting that the recent mixing of strains between countries is not common in this area of Africa. Strains with the Af1-specific deletion (RDAf1) were not identified in M. bovis isolates from Algeria, Burundi, Ethiopia, Madagascar, Mozambique, South Africa, Tanzania, and Uganda. Furthermore, the spoligotype signature of the Af1 clonal complex has not been identified in population samples of bovine tuberculosis from Europe, Iran, and South America. These observations suggest that the Af1 clonal complex is geographically localized, albeit to several African countries, and we suggest that the dominance of the clonal complex in this region is the result of an original introduction into cows naïve to bovine tuberculosis.
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