ArticleAmerican journal of physiology. Lung cellular and molecular physiology2009
Mechanisms of eosinophil major basic protein-induced hyperexcitability of vagal pulmonary chemosensitive neurons.
Article in American journal of physiology. Lung cellular and molecular physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 40 citations in OpenAlex.
- Neuroplasticity and neuroimmune interactions with type 2 inflammation in asthma.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Parasympathetic Airway Hyperreactivity Is Enhanced in Acute but Not Chronic Eosinophilic Asthma Mouse Models.American journal of respiratory cell and molecular biology · 2025Article
- Is fractional exhaled nitric oxide a treatable trait in chronic cough: a narrative review.Journal of thoracic disease · 2023Review
- The diversity of neuroimmune circuits controlling lung inflammation.American journal of physiology. Lung cellular and molecular physiology · 2023Review
- Review
- KThe Journal of physiology · 2022Article
- Improvement of Subjective Olfactory Dysfunction in Chronic Rhinosinusitis With Nasal Polyps After Endoscopic Sinus Surgery.Frontiers in surgery · 2022Article
- Eosinophil extracellular traps drive asthma progression through neuro-immune signals.Nature cell biology · 2021Article
- Capsaicin-Sensitive Vagal Afferent Nerve-Mediated Interoceptive Signals in the Esophagus.Molecules (Basel, Switzerland) · 2021Review
- Airway Sensory Nerve Plasticity in Asthma and Chronic Cough.Frontiers in physiology · 2021Review
- Inflammatory mechanisms linking maternal and childhood asthma.Journal of leukocyte biology · 2020Review
- The Emerging Role of Eosinophils as Multifunctional Leukocytes in Health and Disease.Immune network · 2020Review
- Cough responses to inhaled irritants are enhanced by eosinophil major basic protein in awake mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Transcriptomic Sequencing of Airway Epithelial Cell NCI-H292 Induced by Synthetic Cationic Polypeptides.BioMed research international · 2019Article
- Eosinophil and airway nerve interactions in asthma.Journal of leukocyte biology · 2018Review
- The Role of Eosinophils in Bullous Pemphigoid: A Developing Model of Eosinophil Pathogenicity in Mucocutaneous Disease.Frontiers in medicine · 2018Review
- Role of tissue eosinophils in chronic rhinosinusitis-associated olfactory loss.International forum of allergy & rhinology · 2017Article
- Strontium chloride hexahydrate as a candidate molecule for long-term treatment of allergic rhinitis.The Indian journal of medical research · 2017Article
- Sense and Immunity: Context-Dependent Neuro-Immune Interplay.Frontiers in immunology · 2017Review
- Vagal Afferent Innervation of the Airways in Health and Disease.Physiological reviews · 2016Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have reported recently that eosinophil-derived basic proteins directly enhance the capsaicin- and electrical stimulation-evoked whole cell responses in rat pulmonary sensory neurons (19). Our present study further elucidates the mechanisms underlying the sensitization of pulmonary afferent nerves induced by these cationic proteins. Our results show that pretreatment with eosinophil major basic protein (MBP; 2 microM, 60 s) significantly enhanced the excitability of isolated rat vagal pulmonary chemosensitive neurons to acid and ATP in the current-clamp mode, but this potentiating effect was absent in the voltage-clamp recordings. The hyperexcitability induced by MBP was not prevented by the blockade of either transient receptor potential vanilloid type-1 receptor (TRPV1) selectively (inhibitor: AMG 9810; 1 microM, 2 min) or all TRPV1-4 channels (inhibitor: ruthenium red; 5 microM, 2 min). In addition, MBP also markedly potentiated the excitability of mouse pulmonary chemosensitive neurons, and no detectable difference was found between those isolated from wild-type and TRPV1 knockout mice. Furthermore, MBP pretreatment affected the decay time and recovery phase of the action potentials evoked by current injections and significantly inhibited both the sustained delayed-rectifier voltage-gated K(+) current (IK(dr)) and the A-type, fast-inactivating K(+) current (IK(a)) in these sensory neurons. In conclusion, our results indicate that the inhibition of IK(dr) and IK(a) should, at least in part, account for the hyperexcitability of pulmonary chemosensitive neurons induced by eosinophil-derived cationic proteins, whereas an interaction with TRPV1 channels does not seem to be required for the sensitizing effect of these proteins.
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