ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2009
Effects of brain stem cholecystokinin-8s on gastric tone and esophageal-gastric reflex.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Cholecystokinin Induces CaThe European journal of neuroscience · 2026Article
- Gastric vagal afferent neuropathy following experimental spinal cord injury.Experimental neurology · 2020Article
- Gastrointestinal dysfunction after spinal cord injury.Experimental neurology · 2019Review
- Correlation between the motility of the proximal antrum and the high-frequency power of heart rate variability in freely moving rats.Neurogastroenterology and motility · 2019Article
- Advances in the physiology of gastric emptying.Neurogastroenterology and motility · 2019Review
- Apelin-13 inhibits gastric motility through vagal cholinergic pathway in rats.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
- Vagal neurocircuitry and its influence on gastric motility.Nature reviews. Gastroenterology & hepatology · 2016Review
- High fat diet attenuates glucose-dependent facilitation of 5-HT3 -mediated responses in rat gastric vagal afferents.The Journal of physiology · 2016Article
- Central nervous system control of gastrointestinal motility and secretion and modulation of gastrointestinal functions.Comprehensive Physiology · 2014Review
- Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Ghrelin increases vagally mediated gastric activity by central sites of action.Neurogastroenterology and motility · 2014Article
- Vagal afferent fibres determine the oxytocin-induced modulation of gastric tone.The Journal of physiology · 2013Article
- Roux-en-Y gastric bypass reverses the effects of diet-induced obesity to inhibit the responsiveness of central vagal motoneurones.The Journal of physiology · 2013Article
- A critical re-evaluation of the specificity of action of perivagal capsaicin.The Journal of physiology · 2013Article
- Systemic cholecystokinin amplifies vago-vagal reflex responses recorded in vagal motor neurones.The Journal of physiology · 2012Article
- Upper gastrointestinal dysmotility after spinal cord injury: is diminished vagal sensory processing one culprit?Frontiers in physiology · 2012Article
- CCK stimulation of GLP-1 neurons involves α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs.Diabetes · 2011Article
- Vanilloid, purinergic, and CCK receptors activate glutamate release on single neurons of the nucleus tractus solitarius centralis.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Experimental spinal cord injury in rats diminishes vagally-mediated gastric responses to cholecystokinin-8s.Neurogastroenterology and motility · 2011Article
- Gastric emptying of enterally administered liquid meal in conscious rats and during sustained anaesthesia.Neurogastroenterology and motility · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The actions of cholecystokinin (CCK) on gastrointestinal functions occur mainly via paracrine effects on peripheral sensory vagal fibers, which engage vago-vagal brain stem circuits to convey effector responses back to the gastrointestinal tract. Recent evidence suggests, however, that CCK also affects brain stem structures directly. Many electrophysiological studies, including our own, have shown that brain stem vagal circuits are excited by sulfated CCK (CCK-8s) directly, and we have further demonstrated that CCK-8s induces a remarkable degree of plasticity in GABAergic brain stem synapses. In the present study, we used fasted, anesthetized Sprague-Dawley rats to investigate the effects of brain stem administration of CCK-8s on gastric tone before and after activation of the esophageal-gastric reflex. CCK-8s microinjected in the dorsal vagal complex (DVC) or applied on the floor of the fourth ventricle induced an immediate and transient decrease in gastric tone. Upon recovery of gastric tone to baseline values, the gastric relaxation induced by esophageal distension was attenuated or even reversed. The effects of CCK-8s were antagonized by vagotomy or fourth ventricular, but not intravenous, administration of the CCK-A antagonist lorglumide, suggesting a central, not peripheral, site of action. The gastric relaxation induced by DVC microinjection of CCK-8s was unaffected by pretreatment with systemic bethanecol but was completely blocked by NG-nitro-L-arginine methyl ester, suggesting a nitrergic mechanism of action. These data suggest that 1) brain stem application of CCK-8s induces a vagally mediated gastric relaxation; 2) the CCK-8s-induced gastric relaxation is mediated via activation of nonadrenergic, noncholinergic pathways; and 3) CCK-8s reverses the esophageal-gastric reflex transiently.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.