ArticleAmerican journal of respiratory and critical care medicine2009
Acute lung injury is reduced in fat-1 mice endogenously synthesizing n-3 fatty acids.
Article in American journal of respiratory and critical care medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- The role of fatty acid metabolism in acute lung injury: a special focus on immunometabolism.Cellular and molecular life sciences : CMLS · 2024Pooled it
- Immunomodulation by lipid emulsions in pulmonary inflammation: a randomized controlled trial.Critical care (London, England) · 2015Trial
- Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized, controlled clinical trial.Critical care (London, England) · 2010Trial
- Dietary risk factors for lung cancer: an umbrella review of systematic review and meta-analysis.Translational cancer research · 2026Review
- Omega-3 Fatty Acids and Chronic Lung Diseases: A Narrative Review of Impacts from Womb to Tomb.The Journal of nutrition · 2025Review
- Effects of Omega-3 Polyunsaturated Fatty Acids on the Formation of Adipokines, Cytokines, and Oxylipins in Retroperitoneal Adipose Tissue of Mice.International journal of molecular sciences · 2024Article
- n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout.International journal of molecular sciences · 2023Article
- Importance of Dietary Changes During the Coronavirus Pandemic: How to Upgrade Your Immune Response.Frontiers in public health · 2020Review
- Pretreatment with Fish Oil-Based Lipid Emulsion Modulates Muscle Leukocyte Chemotaxis in Murine Model of Sublethal Lower Limb Ischemia.Mediators of inflammation · 2017Article
- The Omega-3 Fatty Acid Docosahexaenoic Acid Modulates Inflammatory Mediator Release in Human Alveolar Cells Exposed to Bronchoalveolar Lavage Fluid of ARDS Patients.BioMed research international · 2015Article
- Beyond building better brains: bridging the docosahexaenoic acid (DHA) gap of prematurity.Journal of perinatology : official journal of the California Perinatal Association · 2015Review
- Immunomodulation by fish-oil containing lipid emulsions in murine acute respiratory distress syndrome.Critical care (London, England) · 2014Article
- Regulation of Cholesterol Metabolism in Liver: Link to NAFLD and Impact of n-3 PUFAs.Journal of lifestyle medicine · 2013Review
- Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury.Mucosal immunology · 2013Article
- [Nutrition in intensive care medicine: Part 2: special nutritional problems].Der Anaesthesist · 2013Review
- Fat-1 transgenic cattle as a model to study the function of ω-3 fatty acids.Lipids in health and disease · 2011Article
- Fat-1 transgenic mice with elevated omega-3 fatty acids are protected from allergic airway responses.Biochimica et biophysica acta · 2011Article
- The optimal lipid formulation in enteral feeding in critical illness: clinical update and review of the literature.Current gastroenterology reports · 2011Review
- Maternal docosahexaenoic acid supplementation decreases lung inflammation in hyperoxia-exposed newborn mice.The Journal of nutrition · 2011Article
- Acute lung injury: how macrophages orchestrate resolution of inflammation and tissue repair.Frontiers in immunology · 2011Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
Abstract
rationaleAcute lung injury (ALI) remains an important cause of mortality in intensive care units. Inflammation is controlled by cytokines and eicosanoids derived from the n-6 fatty acid (FA) arachidonic acid (AA). The n-3 FA eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and mediators derived from EPA and DHA possess reduced inflammatory potency.
objectivesTo determine whether the ability of fat-1 mice to endogenously convert n-6 to n-3 FA, and thus generate an increased ratio of n-3 to n-6 FA, impacts experimental ALI.
methodsWe investigated ALI induced by intratracheal instillation of endotoxin in fat-1 and wild-type (WT) mice, assessing leukocyte numbers, protein concentration, and prostaglandin and cytokine levels in bronchoalveolar lavage fluid, as well as free FA in plasma, and lung ventilator compliance. Body temperature and motor activity of mice--markers of sickness behavior--were also recorded. MEASUREMENTS AND MAIN
resultsIn ALI, fat-1 mice exhibited significantly reduced leukocyte invasion, protein leakage, and macrophage inflammatory protein-2 and thromboxane B(2) levels in lavage fluid compared with WT mice. Free AA levels were increased in the plasma of WT mice in response to endotoxin, whereas EPA and DHA were increased in the fat-1 group. Ventilator compliance was significantly improved in fat-1 mice. Body temperature and motor activity were decreased in ALI. fat-1 Mice recovered body temperature and motor activity faster.
conclusionsfat-1 Mice exhibited reduced features of ALI and sickness behavior. Increasing the availability of n-3 FA may thus be beneficial in critically ill patients with ALI.
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Registered trials
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