ArticleCell2009
When sirtuins and NF-kappaB collide.
Article in Cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- NADAntioxidants (Basel, Switzerland) · 2023Review
- Modulation of SIRT6 activity acts as an emerging therapeutic implication for pathological disorders in the skeletal system.Genes & diseases · 2023Review
- Deep Neural Network Classifier for Alzheimer's Disease.Journal of student research · 2022Article
- Effect ofBiomedical reports · 2021Article
- Transcription Factors Interplay Orchestrates the Immune-Metabolic Response ofFrontiers in cellular and infection microbiology · 2021Review
- The role of SIRT1 in neuroinflammation and cognitive dysfunction in aged rats after anesthesia and surgery.American journal of translational research · 2019Article
- NAD-Biosynthetic and Consuming Enzymes as Central Players of Metabolic Regulation of Innate and Adaptive Immune Responses in Cancer.Frontiers in immunology · 2019Review
- Sirtuins and Immuno-Metabolism of Sepsis.International journal of molecular sciences · 2018Review
- Nuclear Factor-Kappa B and Alzheimer Disease, Unifying Genetic and Environmental Risk Factors from Cell to Humans.Frontiers in immunology · 2017Review
- Icariin intervenes in cardiac inflammaging through upregulation of SIRT6 enzyme activity and inhibition of the NF-kappa B pathway.BioMed research international · 2015Article
- Oxidative stress induces endothelial cell senescence via downregulation of Sirt6.BioMed research international · 2014Article
- Lipopolysaccharide regulates biosynthesis of cystathionine γ-lyase and hydrogen sulfide through Toll-like receptor-4/p38 and Toll-like receptor-4/NF-κB pathways in macrophages.In vitro cellular & developmental biology. Animal · 2013Article
- Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients.Hepatology (Baltimore, Md.) · 2013Article
- NF-κB inhibition delays DNA damage-induced senescence and aging in mice.The Journal of clinical investigation · 2012Article
- NF-κB, the first quarter-century: remarkable progress and outstanding questions.Genes & development · 2012Review
- NF-κB in Aging and Disease.Aging and disease · 2011Article
- Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation.Journal of leukocyte biology · 2011Review
- Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols.Molecular cancer · 2010Article
- Histone deacetylases and the immunological network: implications in cancer and inflammation.Oncogene · 2010Review
- Skeletal muscle-specific over-expression of the nuclear sirtuin SIRT6 blocks cancer-associated cachexia by regulating multiple targets.JCSM rapid communicationsArticle
Corrections and comments
- Comment on
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both the sirtuins and certain transcription factors of the NF-kappaB/Rel family control aging-associated changes in gene expression. Kawahara et al. (2009) now show a requirement in mice for the sirtuin SIRT6 in dampening NF-kappaB-dependent gene expression, thus unveiling a potential link between inflammation, aging, and metabolism.
Indexed as
Identifiers
19135883What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.