Trial reportPsychoneuroendocrinology2009
Diurnal cortisol amplitude and fronto-limbic activity in response to stressful stimuli.
Trial report in Psychoneuroendocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Functional MRI Techniques Suggesting that the Stress System Interacts with Three Large Scale Core Brain Networks to Help Coordinate the Adaptive Response: A Systematic Review.Current neuropharmacology · 2024Pooled it
- Altered relationship between cortisol response to social stress and mediotemporal function during fear processing in people at clinical high risk for psychosis: a preliminary report.European archives of psychiatry and clinical neuroscience · 2022Trial
- Interindividual differences in stress sensitivity: basal and stress-induced cortisol levels differentially predict neural vigilance processing under stress.Social cognitive and affective neuroscience · 2016Trial
- A randomized, placebo-controlled proof-of-concept, crossover trial of phenytoin for hydrocortisone-induced declarative memory changes.Journal of affective disorders · 2013Trial
- Basal cortisol level modulates stress-induced opioid-seeking behavior.Neurobiology of stress · 2024Article
- Stress-induced brain responses are associated with BMI in women.Communications biology · 2023Article
- Emotional intelligence, distancing, and learning a new skill as strategies to combat the deleterious effects of emotional labor on attorney wellbeing.Frontiers in behavioral neuroscience · 2023Article
- Association of Visual Health With Depressive Symptoms and Brain Imaging Phenotypes Among Middle-Aged and Older Adults.JAMA network open · 2022Article
- Multimodal assessment of sustained threat in adolescents with nonsuicidal self-injury.Development and psychopathology · 2021Article
- Understanding how stress responses and stress-related behaviors have evolved in zebrafish and mammals.Neurobiology of stress · 2021Article
- Cognitive-affective strategies and cortisol stress reactivity in children and adolescents: Normative development and effects of early life stress.Developmental psychobiology · 2019Article
- Neurobiological mechanisms underlying sex-related differences in stress-related disorders: Effects of neuroactive steroids on the hippocampus.Frontiers in neuroendocrinology · 2019Review
- Emotion regulation and cortisol reactivity during a social evaluative stressor: A study of post-institutionalized youth.Developmental psychobiology · 2019Article
- Limbic response to stress linking life trauma and hypothalamus-pituitary-adrenal axis function.Psychoneuroendocrinology · 2019Article
- Sex differences in major depression and comorbidity of cardiometabolic disorders: impact of prenatal stress and immune exposures.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Brain activation during emotion regulation in women with premenstrual dysphoric disorder.Psychological medicine · 2018Article
- Neural - hormonal responses to negative affective stimuli: Impact of dysphoric mood and sex.Journal of affective disorders · 2017Article
- Effect of cortisol diurnal rhythm on emotional memory in healthy young adults.Scientific reports · 2017Article
- The MCP-4/MCP-1 ratio in plasma is a candidate circadian biomarker for chronic post-traumatic stress disorder.Translational psychiatry · 2017Article
- Long-Term Effects of Acute Stress on the Prefrontal-Limbic System in the Healthy Adult.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
The development and exacerbation of many psychiatric and neurologic conditions are associated with dysregulation of the hypothalamic pituitary adrenal (HPA) axis as measured by aberrant levels of cortisol secretion. Here we report on the relationship between the amplitude of diurnal cortisol secretion, measured across 3 typical days in 18 healthy individuals, and blood oxygen level dependant (BOLD) response in limbic fear/stress circuits, elicited by in-scanner presentation of emotionally negative stimuli, specifically, images of the World Trade Center (WTC) attack. Results indicate that subjects who secrete a greater amplitude of cortisol diurnally demonstrate less brain activation in limbic regions, including the amygdala and hippocampus/parahippocampus, and hypothalamus during exposure to traumatic WTC-related images. Such initial findings can begin to link our understanding, in humans, of the relationship between the diurnal amplitude of a hormone integral to the stress response, and those neuroanatomical regions that are implicated as both modulating and being modulated by that response.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.