ArticleFree radical biology & medicine2009
Esterified trityl radicals as intracellular oxygen probes.
Article in Free radical biology & medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 55 citations in OpenAlex.
- Evaluation of Mesoporous Silica Nanoparticles as Carriers of Triarylmethyl Radical Spin Probes for EPR Oximetry.The journal of physical chemistry. B · 2025Article
- Synthesis and characterization of a Cu(ii) coordination-containing TAM radical as a nitroxyl probe.RSC advances · 2022Article
- Dextran-conjugated tetrathiatriarylmethyl radicals as biocompatible spin probes for EPR spectroscopy and imaging.Bioorganic & medicinal chemistry letters · 2019Article
- Injectable, thermosensitive, fast gelation, bioeliminable, and oxygen sensitive hydrogels.Materials science & engineering. C, Materials for biological applications · 2019Article
- A radical containing injectable in-situ-oleogel and emulgel for prolonged in-vivo oxygen measurements with CW EPR.Free radical biology & medicine · 2019Article
- Highly sensitive electron paramagnetic resonance nanoradicals for quantitative intracellular tumor oxymetric images.International journal of nanomedicine · 2019Article
- Development of heme protein based oxygen sensing indicators.Scientific reports · 2018Article
- Single-cell time-lapse imaging of intracellular OCell death & disease · 2017Article
- Triarylmethyl Radicals: EPR Study ofZeitschrift fur physikalische Chemie (Frankfurt am Main, Germany) · 2017Article
- Trityl radicals in perfluorocarbon emulsions as stable, sensitive, and biocompatible oximetry probes.Bioorganic & medicinal chemistry letters · 2016Article
- Facile and High-Yielding Synthesis of TAM Biradicals and Monofunctional TAM Radicals.Synlett : accounts and rapid communications in synthetic organic chemistry · 2016Article
- Poly-arginine conjugated triarylmethyl radical as intracellular spin label.Bioorganic & medicinal chemistry letters · 2016Article
- Characterization of the Binding of the Finland Trityl Radical with Bovine Serum Albumin.RSC advances · 2014Article
- Preparation of Diversely Substituted Triarylmethyl Radicals by the Quenching of Tris(2,3,5,6-tetrathiaaryl)methyl Cations with C-, N-, P-, and S-Nucleophiles.European journal of organic chemistry · 2014Article
- Generation of Trityl Radicals by Nucleophilic Quenching of Tris(2,3,5,6-tetrathiaaryl)methyl Cations and Practical and Convenient Large-Scale Synthesis of Persistent Tris(4-carboxy-2,3,5,6-tetrathiaaryl)methyl Radical.European journal of organic chemistry · 2013Article
- Fast gated EPR imaging of the beating heart: spatiotemporally resolved 3D imaging of free-radical distribution during the cardiac cycle.Magnetic resonance in medicine · 2013Article
- Tetrathiatriarylmethyl radical with a single aromatic hydrogen as a highly sensitive and specific superoxide probe.Free radical biology & medicine · 2012Article
- Optical probes and techniques for O2 measurement in live cells and tissue.Cellular and molecular life sciences : CMLS · 2012Review
- Complexes of Ir(III)-octaethylporphyrin with peptides as probes for sensing cellular O2.Chembiochem : a European journal of chemical biology · 2012Article
- Triarylmethanols bearing bulky aryl groups and the NOESY/EXSY experimental observation of two-ring-flip mechanism for helicity reversal of molecular propellers.European journal of organic chemistry · 2012Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Triarylmethyl (trityl) radicals exhibit high stability and narrow linewidth under physiological conditions which provide high sensitivity and resolution for the measurement of O2 concentrations, making them attractive as EPR oximetry probes. However, the application of previously available compounds has been limited by their poor intracellular permeability. We recently reported the synthesis and characterization of esterified trityl radicals as potential intracellular EPR probes and their oxygen sensitivity, redox properties, and enzyme-mediated hydrolysis were investigated. In this paper, we report the cellular permeability and stability of these trityls in the presence of bovine aortic endothelial cells. Results show that the acetoxymethoxycarbonyl-containing trityl AMT-02 exhibits high stability in the presence of cells and can be effectively internalized. The intracellular hydrolysis of AMT-02 to the carboxylate form of the trityl (CT-03) was also observed. In addition, this internalized trityl probe was applied to measure intracellular O2 concentrations and the effects of menadione and KCN on the rates of O2 consumption in endothelial cells. This study demonstrates that these esterified trityl radicals can function as effective EPR oximetry probes measuring intracellular O2 concentration and consumption.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.