ArticleToxicology and applied pharmacology2009
Nickel compounds induce apoptosis in human bronchial epithelial Beas-2B cells by activation of c-Myc through ERK pathway.
Article in Toxicology and applied pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
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- Molecular Health Effects of Electronic Cigarettes.Biomolecules · 2026Review
- Development of an integrated testing strategy using in vitro models to predict lung carcinogenesis.Environmental analysis, health and toxicology · 2025Article
- Toxicological Aspects Associated with Consumption from Electronic Nicotine Delivery System (ENDS): Focus on Heavy Metals Exposure and Cancer Risk.International journal of molecular sciences · 2024Review
- Nickel chloride administration prevents the growth of oral squamous cell carcinoma.Oncotarget · 2018Article
- Chemical-agnostic hazard prediction: statistical inference ofComputational toxicology (Amsterdam, Netherlands) · 2017Article
- Protective Effects of Gallic Acid Against NiSO4-Induced Toxicity Through Down-Regulation of the Ras/ERK Signaling Pathway in Beas-2B Cells.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- In vitro and in vivo evaluation of the toxicities induced by metallic nickel nano and fine particles.Journal of molecular histology · 2016Article
- Two COX-2 inhibitors induce apoptosis in human erythroleukemia K562cells by modulating NF-κB and FHC pathways.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2016Article
- Research Advances on Pathways of Nickel-Induced Apoptosis.International journal of molecular sciences · 2015Review
- Epigenetic dysregulation by nickel through repressive chromatin domain disruption.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Toxicogenomic effect of nickel and beyond.Archives of toxicology · 2014Review
- Anti-apoptotic proteins and catalase-dependent apoptosis resistance in nickel chloride-transformed human lung epithelial cells.International journal of oncology · 2013Article
- Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro.Toxicology and applied pharmacology · 2012Article
- Exploring the molecular mechanisms of nickel-induced genotoxicity and carcinogenicity: a literature review.Reviews on environmental health · 2011Review
- Nickel sulfate induces location-dependent atrophy of mouse olfactory epithelium: protective and proliferative role of purinergic receptor activation.Toxicological sciences : an official journal of the Society of Toxicology · 2010Article
- Reactive oxygen species-activated Akt/ASK1/p38 signaling pathway in nickel compound-induced apoptosis in BEAS 2B cells.Chemical research in toxicology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Nickel compounds are carcinogenic to humans and have been shown to alter epigenetic homeostasis. The c-Myc protein controls 15% of human genes and it has been shown that fluctuations of c-Myc protein alter global epigenetic marks. Therefore, the regulation of c-Myc by nickel ions in immortalized but not tumorigenic human bronchial epithelial Beas-2B cells was examined in this study. It was found that c-Myc protein expression was increased by nickel ions in non-tumorigenic Beas-2B and human keratinocyte HaCaT cells. The results also indicated that nickel ions induced apoptosis in Beas-2B cells. Knockout of c-Myc and its restoration in a rat cell system confirmed the essential role of c-Myc in nickel ion-induced apoptosis. Further studies in Beas-2B cells showed that nickel ion increased the c-Myc mRNA level and c-Myc promoter activity, but did not increase c-Myc mRNA and protein stability. Moreover, nickel ion upregulated c-Myc in Beas-2B cells through the MEK/ERK pathway. Collectively, the results demonstrate that c-Myc induction by nickel ions occurs via an ERK-dependent pathway and plays a crucial role in nickel-induced apoptosis in Beas-2B cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.