Evidence map›Paper›PMID 19135385›Full record

ArticleJournal of the American Society for Mass Spectrometry2009

A novel approach to collision-induced dissociation (CID) for ion mobility-mass spectrometry experiments.

Christopher Becker, Francisco A Fernandez-Lima, Kent J Gillig, William K Russell, Stephanie M Cologna, David H Russell

Abstract read
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In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christopher BeckerThe Laboratory for Biological Mass Spectrometry, Department of Chemistry, Texas A and M University, College Station, Texas 77843-3255, USA.
Francisco A Fernandez-Lima
Kent J Gillig
William K Russell
Stephanie M Cologna
David H Russell

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Collision induced dissociation (CID) combined with matrix assisted laser desorption ionization-ion mobility-mass spectrometry (MALDI-IM-MS) is described. In this approach, peptide ions are separated on the basis of mobility in a 15 cm drift cell. Following mobility separation, the ions exit the drift cell and enter a 5 cm vacuum interface with a high field region (up to 1000 V/cm) to undergo collisional activation. Ion transmission and ion kinetic energies in the interface are theoretically evaluated accounting for the pressure gradient, interface dimensions, and electric fields. Using this CID technique, we have successfully fragmented and sequenced a number of model peptide ions as well as peptide ions obtained by a tryptic digest. This instrument configuration allows for the simultaneous determination of peptide mass, peptide-ion sequence, and collision-cross section of MALDI-generated ions, providing information critical to the identification of unknown components in complex proteomic samples.

Indexed as

Computer SimulationEquipment DesignFibrinopeptide AModels, ChemicalPeptide FragmentsPressureProteinsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationTrypsinFibrinopeptide APeptide FragmentsProteinsTrypsin

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.