ReviewDrug and alcohol dependence2009
Sex heterogeneity in pharmacogenetic smoking cessation clinical trials.
Review in Drug and alcohol dependence, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Factors associated with the efficacy of smoking cessation treatments and predictors of smoking abstinence in EAGLES.Addiction (Abingdon, England) · 2018Trial
- Nicotine dependence as a moderator of a quitline-based message framing intervention.Drug and alcohol dependence · 2011Trial
- Melanin-Concentrating Hormone (MCH): Role in Mediating Reward-Motivated and Emotional Behavior and the Behavioral Disturbances Produced by Repeated Exposure to Reward Substances.International journal of molecular sciences · 2025Review
- Ovarian hormones, menstrual cycle phase, and smoking: a review with recommendations for future studies.Current addiction reports · 2016Article
- Gender Considerations in Addiction: Implications for Treatment.Current treatment options in psychiatry · 2015Article
- The relationship between the nicotine metabolite ratio and three self-report measures of nicotine dependence across sex and race.Psychopharmacology · 2014Article
- Pharmacogenetics of nicotine addiction: role of dopamine.Pharmacogenomics · 2014Review
- Gold standard program for heavy smokers in a real-life setting.International journal of environmental research and public health · 2013Article
- Gender-stratified gene and gene-treatment interactions in smoking cessation.The pharmacogenomics journal · 2012Article
- Women and smoking: an interdisciplinary examination of socioeconomic influences.Drug and alcohol dependence · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Approximately one-quarter of smokers who use treatments for nicotine dependence are able to achieve cessation. However, there is evidence that women do not respond as well to nicotine replacement therapy (NRT) and, perhaps, to bupropion, compared to men. In this contribution to the Special Issue of Drug and Alcohol Dependence concerning Women and Smoking, we begin with a brief overview of data supporting the role of sex in influencing response to NRT and bupropion. Next, we summarize the results of pharmacogenetic smoking cessation clinical trials which assessed sex as a moderator as well. A relatively small number of pharmacogenetic studies of nicotine dependence treatments have been conducted and five studies reported sex effects in these trials. Of these trials, sex moderated the association of genetic variation in drug pharmacokinetics or pharmacodynamics and treatment response. We conclude this paper with a summary and a brief discussion of the major caveats of this literature and priorities for future research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.