ArticleDevelopmental biology2009
Increased thymus- and decreased parathyroid-fated organ domains in Splotch mutant embryos.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 56 citations in OpenAlex.
- It's Time to Unite: Diversity and Coordination of Thymic Stromal Cells for T Cell Selection and Organ Integrity.Immunological reviews · 2025Review
- Thymus Ontogeny and Development.Advances in experimental medicine and biology · 2025Review
- Cellular and molecular mechanisms of the organogenesis and development, and function of the mammalian parathyroid gland.Cell and tissue research · 2023Review
- Non-Epithelial Stromal Cells in Thymus Development and Function.Frontiers in immunology · 2021Review
- Thymus Inception: Molecular Network in the Early Stages of Thymus Organogenesis.International journal of molecular sciences · 2020Review
- Molecular Insights Into the Causes of Human Thymic Hypoplasia With Animal Models.Frontiers in immunology · 2020Review
- T-Cell Immunodeficiencies With Congenital Alterations of Thymic Development: Genes Implicated and Differential Immunological and Clinical Features.Frontiers in immunology · 2020Review
- Tissue-specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate.Development (Cambridge, England) · 2016Article
- Dynamic epithelia of the developing vertebrate face.Current opinion in genetics & development · 2015Review
- Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse.Development (Cambridge, England) · 2014Article
- Thymus involution and regeneration: two sides of the same coin?Nature reviews. Immunology · 2013Review
- Dynamics of thymus organogenesis and colonization in early human development.Development (Cambridge, England) · 2013Article
- Early development of the thymus in Xenopus laevis.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Article
- Cell-autonomous defects in thymic epithelial cells disrupt endothelial-perivascular cell interactions in the mouse thymus.PloS one · 2013Article
- Mechanisms of thymus organogenesis and morphogenesis.Development (Cambridge, England) · 2011Review
- Functional interaction between Foxd3 and Pax3 in cardiac neural crest development.Genesis (New York, N.Y. : 2000) · 2011Article
- Thymopoiesis in mice depends on a Foxn1-positive thymic epithelial cell lineage.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- EphB-ephrin-B2 interactions are required for thymus migration during organogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2.The Journal of clinical investigation · 2010Article
- Evidence for an early role for BMP4 signaling in thymus and parathyroid morphogenesis.Developmental biology · 2010Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Embryos that are homozygous for Splotch, a null allele of Pax3, have a severe neural crest cell (NCC) deficiency that generates a complex phenotype including spina bifida, exencephaly and cardiac outflow tract abnormalities. Contrary to the widely held perception that thymus aplasia or hypoplasia is a characteristic feature of Pax3(Sp/Sp) embryos, we find that thymic rudiments are larger and parathyroid rudiments are smaller in E11.5-12.5 Pax3(Sp/Sp) compared to Pax3(+/+) embryos. The thymus originates from bilateral third pharyngeal pouch primordia containing endodermal progenitors of both thymus and parathyroid glands. Analyses of Foxn1 and Gcm2 expression revealed a dorsal shift in the border between parathyroid- and thymus-fated domains at E11.5, with no change in the overall cellularity or volume of each shared primordium. The border shift increases the allocation of third pouch progenitors to the thymus domain and correspondingly decreases allocation to the parathyroid domain. Initial patterning in the E10.5 pouch was normal suggesting that the observed change in the location of the organ domain interface arises during border refinement between E10.5 and E11.5. Given the well-characterized NCC defects in Splotch mutants, these findings implicate NCCs in regulating patterning of third pouch endoderm into thymus- versus parathyroid-specified domains, and suggest that organ size is determined in part by the number of progenitor cells specified to a given fate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.