ArticleBipolar disorders2009
Comparison of manic and depressive symptoms between children and adolescents with bipolar spectrum disorders.
Article in Bipolar disorders, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Brain changes in early-onset bipolar and unipolar depressive disorders: a systematic review in children and adolescents.European child & adolescent psychiatry · 2014Pooled it
- Additive impulsivity and emotion dysregulation in adolescents with comorbid bipolar and substance use disorder: a cross-sectional factorial study.Frontiers in psychiatry · 2026Article
- Towards a neurodevelopmental model of bipolar disorder: a critical review of trait- and state-related functional neuroimaging in adolescents and young adults.Molecular psychiatry · 2025Review
- Article
- How to treat major depressive disorder with shorter-duration hypomanic episodes? A case report.Frontiers in psychiatry · 2024Article
- Cognitive, Family, and Quality-of-Life Characteristics of Youth with Depression Associated with Bipolar Disorder.Journal of child and adolescent psychopharmacology · 2023Article
- A graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults.Journal of affective disorders · 2022Article
- Prospectively ascertained mania and hypomania among young adults with child- and adolescent-onset bipolar disorder.Bipolar disorders · 2021Article
- Sex Differences in the Longitudinal Course and Outcome of Bipolar Disorder in Youth.The Journal of clinical psychiatry · 2020Article
- Functional Impairment and Clinical Correlates in Adolescents with Bipolar Disorder Compared to Healthy Controls. A Case-control Study.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2020Article
- Suicide Ideation in Adolescents Following Inpatient Hospitalization: Examination of Intensity and Lability Over 6 Months.Suicide & life-threatening behavior · 2019Article
- Bipolar spectrum in major depressive disorders.European archives of psychiatry and clinical neuroscience · 2018Article
- Parsing cyclothymic disorder and other specified bipolar spectrum disorders in youth.Journal of affective disorders · 2018Article
- Mood instability as a predictor of clinical and functional outcomes in adolescents with bipolar I and bipolar II disorder.Journal of affective disorders · 2018Article
- The Influence of Myelin Oligodendrocyte Glycoprotein on White Matter Abnormalities in Different Onset Age of Drug-Naïve Depression.Frontiers in psychiatry · 2018Article
- A systematic review of the frequency and severity of manic symptoms reported in studies that compare phenomenology across children, adolescents and adults with bipolar disorders.International journal of bipolar disorders · 2017Review
- Pediatric Mania: The Controversy between Euphoria and Irritability.Current neuropharmacology · 2017Review
- Similarities and differences of functional connectivity in drug-naïve, first-episode adolescent and young adult with major depressive disorder and schizophrenia.Scientific reports · 2017Article
- Understanding Early Age of Onset: a Review of the Last 5 Years.Current psychiatry reports · 2016Review
- Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveTo compare the most severe lifetime (current or past) mood symptoms, duration of illness, and rates of lifetime comorbid disorders among youth with bipolar spectrum disorders [BP (bipolar-I, bipolar-II and bipolar-not otherwise specified)].
methodsA total of 173 children (<12 years) with BP, 101 adolescents with childhood-onset BP, and 90 adolescents with adolescent-onset BP were evaluated with standardized instruments.
resultsDepression was the most common initial and frequent episode for both adolescent groups, followed by mania/hypomania. Adolescents with childhood-onset BP had the longest illness, followed by children and then adolescents with adolescent-onset BP. Adjusting for sex, socioeconomic status, and duration of illness, while manic, both adolescent groups showed more 'typical' and severe manic symptoms. Mood lability was more frequent in childhood-onset and adolescents with early-onset BP. While depressed, both adolescent groups showed more severe depressive symptoms, higher rates of melancholic and atypical symptoms, and suicide attempts than children. Depressed children had more severe irritability than depressed adolescents. Early BP onset was associated with attention-deficit hyperactivity disorder, whereas later BP onset was associated with panic, conduct, and substance use disorders. Above-noted results were similar when each BP subtype was analyzed separately.
conclusionsOlder age was associated with more severe and typical mood symptomatology. However, there were differences and similarities in type, intensity, and frequency of BP symptoms and comorbid disorders related to age of onset and duration of BP and level of psychosocial development. These factors and the normal difficulties youth have expressing and modulating their emotions may explain existing complexities in diagnosing and treating BP in youth, particular in young children, and suggest the need for developmentally sensitive treatments.
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Registered trials
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