ArticleJournal of materials science. Materials in medicine2009
Feasibility of biodegradable PLGA common bile duct stents: an in vitro and in vivo study.
Article in Journal of materials science. Materials in medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Biliary Injuries Repair Using Copolymeric Scaffold: A Systematic Review and In Vivo Experimental Study.Journal of functional biomaterials · 2025Article
- Biodegradable Stents in Companion Animals: A Systematic Scoping Review.Veterinary medicine international · 2025Review
- Biliary stents for active materials and surface modification: Recent advances and future perspectives.Bioactive materials · 2024Review
- The past, present, and future of endoscopic management for biliary strictures: technological innovations and stent advancements.Frontiers in medicine · 2024Review
- Development of a thick and functional human adipose-derived stem cell tissue sheet for myocardial infarction repair in rat hearts.Stem cell research & therapy · 2023Article
- A review on biodegradable biliary stents: materials and future trends.Bioactive materials · 2022Review
- Biliary complications after liver transplantation: current perspectives and future strategies.Hepatobiliary surgery and nutrition · 2021Review
- Biocompatible Polymer Materials with Antimicrobial Properties for Preparation of Stents.Nanomaterials (Basel, Switzerland) · 2019Review
- The effect of mechanical loads on the degradation of aliphatic biodegradable polyesters.Regenerative biomaterials · 2017Review
- In vitro and in vivo assessment of the biocompatibility of an Mg-6Z(n) alloy in the bile.Journal of materials science. Materials in medicine · 2014Article
- Technique for the safe placement of a biodegradable stent into the common bile duct of rabbits.Experimental and therapeutic medicine · 2013Article
- Repair of bile duct defect with degradable stent and autologous tissue in a porcine model.World journal of gastroenterology · 2012Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current study investigates the feasibility of using a biodegradable polymeric stent in common bile duct (CBD) repair and reconstruction. Here, poly(L-lactide-co-glycolide) (PLGA, molar ratio LA/GA = 80/20) was processed into a circular tube- and dumbbell-shaped specimens to determine the in vitro degradation behavior in bile. The morphology, weight loss, and molecular weight changes were then investigated in conjunction with evaluations of the mechanical properties of the specimen. Circular tube-shaped PLGA stents with X-ray opacity were subsequently used in common bile duct exploration (CBDE) and primary suturing in canine models. Next, X-ray images of CBD stents in vivo were compared and levels of serum liver enzymes and a histological analysis were conducted after stent transplantation. The results showed that the PLGA stents exhibited the required biomedical properties and spontaneously disappeared from CBDs in 4-5 weeks. The degradation period and function match the requirements in repair and reconstruction of CBDs to support the duct, guide bile drainage, and reduce T-tube-related complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.