Evidence map›Paper›PMID 19132482›Full record

ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2008

Detection of micrometastases in peritoneal washings of gastric cancer patients by the reverse transcriptase polymerase chain reaction.

Kimberly Moore Dalal, Yanghee Woo, Kaitlyn Kelly, Charles Galanis, Mithat Gonen, Yuman Fong, Daniel G Coit

Open access · bronzeAbstract read
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In one paragraph

Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
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  12. Rt-PCR increases detection of submicroscopic peritoneal metastases in gastric cancer and has prognostic significance.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2012
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  13. Review
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  16. Disseminated cancer cells in the peritoneal cavity: what can we do when we detect them?Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2008
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kimberly Moore DalalDepartment of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York NY, 10021, USA.
Yanghee Woo
Kaitlyn Kelly
Charles Galanis
Mithat Gonen
Yuman Fong
Daniel G Coit
Memorial Sloan Kettering Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastric cancer patients with positive (+) peritoneal cytology have a prognosis similar to stage IV patients. We studied the ability of quantitative reverse transcriptase polymerase chain reaction (RT-PCR) to detect peritoneal micrometastases in patients undergoing staging laparoscopy.

methodsPeritoneal washings were obtained prospectively from 34 patients with gastric adenocarcinoma undergoing staging laparoscopy and 6 patients undergoing laparoscopy for benign disease. Each sample underwent cytologic and RT-PCR analysis for tumor markers: carcinoembryonic antigen (CEA), cytokeratin 20 (CK20), survivin, and MUC2. Markers were evaluated on the basis of their deviance from the ideal marker.

resultsPathologic stages for the gastric cancer patients were: stage I, 9 (27%); stage II, 7 (21%); stage III, 15 (44%); and stage IV, 3 (9%). The four cytology (+) patients were: stage II, 1; stage III, 1; and stage IV, 2. Fifteen patients were RT-PCR (+), including all cytology (+) patients. The optimal threshold for cycle amplification was 35, based on a receiver operating characteristic curve. CEA had the smallest deviance.

conclusionRT-PCR using a panel of tumor markers, including CEA, detects (+) cytology. The clinical significance of "false-positive" overexpression of CEA, survivin, or CK20 but cytology (-) remains to be defined. RT-PCR could represent a more sensitive method than cytology for detection of subclinical peritoneal tumor dissemination; this may be useful in improving patient selection for operative management and clinical trials.

Indexed as

Reverse Transcriptase Polymerase Chain ReactionAdenocarcinomaAdultAgedAged, 80 and overBiomarkers, TumorCarcinoembryonic AntigenFemaleHumansInhibitor of Apoptosis ProteinsKeratin-20LaparoscopyMaleMicrotubule-Associated ProteinsMiddle AgedMucin-2Biomarkers, TumorBIRC5 protein, humanCarcinoembryonic AntigenInhibitor of Apoptosis ProteinsKeratin-20Microtubule-Associated ProteinsMUC2 protein, humanMucin-2RNA, MessengerSurvivin

Identifiers

PMID19132482
OpenAlexW2108072930

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.