ArticleHuman genetics2009
Uterine leiomyomata and decreased height: a common HMGA2 predisposition allele.
Article in Human genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Genome-wide linkage and association analyses implicate FASN in predisposition to Uterine Leiomyomata.American journal of human genetics · 2012Pooled it
- Integrated genetic and clinical investigation of autosomal dominant hereditary uterine leiomyomas: genotype-phenotype correlation in a pakistani family.Molecular biology reports · 2026Article
- High mobility group protein 2 (HMGA2) is highly expressed in a broad range of benign and malignant tumors.Virchows Archiv : an international journal of pathology · 2025Article
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- Article
- Clinical, pathologic, cytogenetic, and molecular profiling in self-identified black women with uterine leiomyomata.Cancer genetics · 2018Article
- Genome-wide association study reveals genetic loci and candidate genes for average daily gain in Duroc pigs.Asian-Australasian journal of animal sciences · 2018Article
- Immunoexpression of Steroid Hormone Receptors and Proliferation Markers in Uterine Leiomyoma and Normal Myometrial Tissues from the Miniature Pig, Sus scrofa.Toxicologic pathology · 2016Article
- Genetic determinants of uterine fibroid size in the multiethnic NIEHS uterine fibroid study.International journal of molecular epidemiology and genetics · 2015Article
- Hmga1/Hmga2 double knock-out mice display a "superpygmy" phenotype.Biology open · 2014Article
- The health disparities of uterine fibroid tumors for African American women: a public health issue.American journal of obstetrics and gynecology · 2014Review
- Association of genetic variations in RTN4 3'-UTR with risk of uterine leiomyomas.Pathology oncology research : POR · 2013Article
- Variations in the PDCD6 gene are associated with increased uterine leiomyoma risk in the Chinese.Genetic testing and molecular biomarkers · 2013Article
- Self-reported family history of leiomyoma: not a reliable marker of high risk.Annals of epidemiology · 2013Article
- Uterine fibroids: pathogenesis and interactions with endometrium and endomyometrial junction.Obstetrics and gynecology international · 2013Review
- Leiomyoma: genetics, assisted reproduction, pregnancy and therapeutic advances.Journal of assisted reproduction and genetics · 2012Review
- Expression profiling of uterine leiomyomata cytogenetic subgroups reveals distinct signatures in matched myometrium: transcriptional profilingof the t(12;14) and evidence in support of predisposing genetic heterogeneity.Human molecular genetics · 2012Article
- Genetic architecture of body size in mammals.Genome biology · 2012Review
- Proceedings from theNational Institute of Child Health and Human Development conference on the Uterine Fibroid Research Update Workshop.Fertility and sterility · 2011Article
- Disseminated peritoneal leiomyomatosis after laparoscopic supracervical hysterectomy with characteristic molecular cytogenetic findings of uterine leiomyoma.Genes, chromosomes & cancer · 2010Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
Uterine leiomyomata (UL) are the most common female pelvic tumors and the primary indication for hysterectomy in the United States. We assessed genetic liability for UL by a known embryonic proliferation modulator, HMGA2, in 248 families ascertained through medical record-confirmed affected sister-pairs. Using a (TC)( n ) repeat in the 5' UTR and 17 SNPs spanning HMGA2, permutation-based association tests identified a significant increase in transmission of a single TC repeat allele (TC227) with UL (allele-specific P = 0.00005, multiple testing corrected min-P = 0.0049). The hypothesis that TC227 is a pathogenic variant is supported by a trend towards higher HMGA2 expression in TC227 allele-positive compared with non-TC227 UL tissue as well as by absence of culpable exonic sequence variants. HMGA2 has also been suggested recently by three genome-wide SNP studies to influence human height variation, and our examination of the affected sister-pair families revealed a significant association of TC227 with decreased height (allele-specific P = 0.00033, multiple testing corrected min-P = 0.016). Diminished stature and elevated risk of UL development have both been correlated with an earlier age of menarche, which may be the biological mechanism for TC227 effects as a tendency of women with TC227 to have an earlier onset of menarche was identified in our study population. These results indicate HMGA2 has a role in two growth-related phenotypes, UL predisposition and height, of which the former may affect future medical management decisions for many women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.