ArticlePsychopharmacology2009
The adenosine A2A antagonist MSX-3 reverses the effects of the dopamine antagonist haloperidol on effort-related decision making in a T-maze cost/benefit procedure.
Article in Psychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 114 citations in OpenAlex.
- Conjoint influence of effort and delay in decision making and its implication for the neural mechanisms of choice.Cognitive, affective & behavioral neuroscience · 2026Article
- Developmental exposure to 17-α-hydroxyprogesterone caproate disrupts decision-making in adult female rats: A potential role for a dopaminergic mechanism.Hormones and behavior · 2024Article
- Effort-related effects of chronic administration of the DA DPsychopharmacology · 2023Article
- Ventral Tegmental Area M5 Muscarinic Receptors Mediate Effort-Choice Responding and Nucleus Accumbens Dopamine in a Sex-Specific Manner .The Journal of pharmacology and experimental therapeutics · 2023Article
- Neural representation and modulation of volitional motivation in response to escalating efforts.The Journal of physiology · 2023Article
- AInternational review of neurobiology · 2023Article
- Haloperidol-Induced Immediate Early Genes in Striatopallidal Neurons Requires the Converging Action of cAMP/PKA/DARPP-32 and mTOR Pathways.International journal of molecular sciences · 2022Article
- The Arousal-motor Hypothesis of Dopamine Function: Evidence that Dopamine Facilitates Reward Seeking in Part by Maintaining Arousal.Neuroscience · 2022Article
- Cholinergic and dopaminergic-mediated motivated behavior in healthy states and in substance use and mood disorders.Journal of the experimental analysis of behavior · 2022Review
- Vigor, Effort-Related Aspects of Motivation and Anhedonia.Current topics in behavioral neurosciences · 2022Review
- Evidence for Protein-Protein Interaction between Dopamine Receptors and the G Protein-Coupled Receptor 143.International journal of molecular sciences · 2021Article
- Sex differences in effort-related decision-making: role of dopamine D2 receptor antagonism.Psychopharmacology · 2021Article
- Lateral Habenula Inactivation Alters Willingness to Exert Physical Effort Using a Maze Task in Rats.Frontiers in behavioral neuroscience · 2021Article
- Inhibition of Catechol-Frontiers in behavioral neuroscience · 2020Article
- Blockade of muscarinic acetylcholine receptors facilitates motivated behaviour and rescues a model of antipsychotic-induced amotivation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Preference for Exercise vs. More Sedentary Reinforcers: Validation of an Animal Model of Tetrabenazine-Induced Anergia.Frontiers in behavioral neuroscience · 2019Article
- A Novel Weight Lifting Task for Investigating Effort and Persistence in Rats.Frontiers in behavioral neuroscience · 2019Article
- New Developments on the Adenosine Mechanisms of the Central Effects of Caffeine and Their Implications for Neuropsychiatric Disorders.Journal of caffeine and adenosine research · 2018Review
- The Psychopharmacology of Effort-Related Decision Making: Dopamine, Adenosine, and Insights into the Neurochemistry of Motivation.Pharmacological reviews · 2018Review
- Caffeine and Selective Adenosine Receptor Antagonists as New Therapeutic Tools for the Motivational Symptoms of Depression.Frontiers in pharmacology · 2018Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
rationaleMesolimbic dopamine (DA) is a critical component of the brain circuitry regulating behavioral activation and effort-related processes. Research involving choice tasks has shown that rats with impaired DA transmission reallocate their instrumental behavior away from food-reinforced tasks with high response requirements and instead select less effortful food-seeking behaviors.
objectivePrevious work showed that adenosine A(2A) antagonism can reverse the effects of the DA antagonist haloperidol in an operant task that assesses effort-related choice. The present work used a T-maze choice procedure to assess the effects of adenosine A(2A) and A(1) antagonism. MATERIALS AND
methodsWith this task, the two arms of the maze have different reinforcement densities (four vs. two food pellets), and a vertical 44 cm barrier is positioned in the arm with the higher density, presenting the animal with an effort-related challenge. Untreated rats strongly prefer the arm with the high density of food reward and climb the barrier in order to obtain the food.
resultsHaloperidol produced a dose-related (0.05-0.15 mg/kg i.p.) reduction in the number of trials in which the rats chose the high-barrier arm. Co-administration of the adenosine A(2A) receptor antagonist MSX-3 (0.75, 1.5, and 3.0 mg/kg i.p.), but not the A(1) antagonist 8-cyclopentyl-1,3-dipropylxanthine (0.75, 1.5, and 3.0 mg/kg i.p.), reversed the effects of haloperidol on effort-related choice and latency.
conclusionsAdenosine A(2A) and D2 receptors interact to regulate effort-related decision making, which may have implications for the treatment of psychiatric symptoms such as psychomotor slowing or anergia that can be observed in depression, parkinsonism, and other disorders.
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