ReviewIntensive care medicine2009
Mini-series: II. clinical aspects. clinically relevant CYP450-mediated drug interactions in the ICU.
Review in Intensive care medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02868827 (Cholecalciferol Supplementation in Critically Ill Patients With Severe Vitamin D Deficiency in Intensive Care Unit- A Randomized Controlled Trial.), which is not on this map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cholecalciferol Supplementation in Critically Ill Patients With Severe Vitamin D Deficiency in Intensive Care Unit- A Randomized Controlled Trial.
Who cites it
23 citing papers in PubMed, 74 citations in OpenAlex.
- Effect of vitamin D3 on bone turnover markers in critical illness: post hoc analysis from the VITdAL-ICU study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Trial
- Birthweight and cytochrome P4503A4/5 activity in obese women.British journal of clinical pharmacology · 2013Trial
- Effect of Single High Dose Vitamin D Administration in Critically Ill Vitamin D-deficient Pediatric Patients: A Randomized Trial.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Vitamin D Deficiency: An Underestimated Factor in Sepsis?International journal of molecular sciences · 2023Review
- Pharmacokinetic Alterations Associated with Critical Illness.Clinical pharmacokinetics · 2023Review
- Clinical pharmacist assessment of drug-related problems among intensive care unit patients in a Turkish university hospital.BMC health services research · 2022Article
- Concomitant Treatment with Voriconazole and Flucloxacillin: A Combination to Avoid.Antibiotics (Basel, Switzerland) · 2021Article
- Severe Potential Drug-Drug Interactions and the Increased Length of Stay of Children in Intensive Care Unit.Frontiers in pharmacology · 2020Article
- The effect of different intensivist staffing patterns on the rate of potential drug-drug interactions in adult trauma intensive care units.Therapeutic advances in drug safety · 2020Article
- Impact of clinical pharmacist in an Indian Intensive Care Unit.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2016Article
- Chasing the elusive notion of delirium causality.Intensive care medicine · 2015Article
- Clinical relevancy and risks of potential drug-drug interactions in intensive therapy.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2015Article
- Expression of arachidonic acid-metabolizing cytochrome P450s in human megakaryocytic Dami cells.In vitro cellular & developmental biology. Animal · 2013Article
- Evaluation of adverse drug reactions in medical intensive care units.European journal of clinical pharmacology · 2013Article
- [Drug-induced long QT syndrome. Relevancy in intensive care medicine].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2012Review
- Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest.Critical care medicine · 2012Article
- Attenuated hypocholesterolemia following severe trauma signals risk for late ventilator-associated pneumonia, ventilator dependency, and death: a retrospective study of consecutive patients.Lipids in health and disease · 2011Article
- Prevalence of potential drug interactions in patients in an intensive care unit of a university hospital in Brazil.Clinics (Sao Paulo, Brazil) · 2011Article
- Evaluation of three brands of drug interaction software for use in intensive care units.Pharmacy world & science : PWS · 2010Article
- Drug-drug interactions in cardiac and cardiothoracic intensive care units: an analysis of patients in an academic medical centre in the US.Drug safety · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the critically ill, multiple drug therapies for acute and chronic conditions are often used at the same time and adverse drug events occur frequently. Many pharmacological and disease-related factors, e.g. altered renal and hepatic function, catecholamine-related circulatory changes, altered drug volume of distribution, enteral versus parenteral feeding and morbid obesity, along with concomitant multiple drug regimens may account for the wide inter-individual variability in drug exposure and response in critically ill patients and for the high risk for drug-drug interactions to occur. The practicing intensivist must remain aware of the major mechanisms for drug-drug interactions, among which the drug-metabolizing enzyme inhibitory or induction potential of associated chemical entities are paramount. Metabolism-based drug-drug interactions are largely due to changes in levels of drug-metabolizing enzymes caused by one drug, leading to changes in the systemic exposure clearance of another. Among the numerous drug-metabolizing enzymes identified to date, the activity of cytochrome P450s (CYP450) is a critical determinant of drug clearance and appears to be involved in the mechanism of numerous clinically relevant drug-drug interactions observed in critically ill patients. DISCUSSION: This manuscript will cover a practical overview of clinically relevant CYP450-mediated drug-drug interactions. Medications frequently used in the intensive care unit such as benzodiazepines, immunosuppressive agents, opioid analgesics, certain anticonvulsants, the azoles and macrolides have the potential to interact with CYP450-mediated metabolism and may lead to toxicity or therapeutic failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.