ReviewDisease models & mechanisms
Fishing for the genetic basis of cardiovascular disease.
Review in Disease models & mechanisms. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 75 citations in OpenAlex.
- Ddx3xa mutations drive cardiac defects in a zebrafish model via dysregulation of wnt/β-catenin signaling.Frontiers in molecular biosciences · 2025Article
- An inherited life-threatening arrhythmia model established by screening randomly mutagenized mice.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Contribution of model organism phenotypes to the computational identification of human disease genes.Disease models & mechanisms · 2022Article
- Research('s) Sweet Hearts: Experimental Biomedical Models of Diabetic Cardiomyopathy.Frontiers in cardiovascular medicine · 2021Review
- Zebrafish Heart Failure Models.Frontiers in cell and developmental biology · 2021Review
- High-frequency ultrasound deformation imaging for adult zebrafish during heart regeneration.Quantitative imaging in medicine and surgery · 2020Article
- Bitter gourd (Momordica charantia) possess developmental toxicity as revealed by screening the seeds and fruit extracts in zebrafish embryos.BMC complementary and alternative medicine · 2019Article
- New perspectives: systems medicine in cardiovascular disease.BMC systems biology · 2018Article
- Genetics of Cardiovascular Disease: Fishing for Causality.Frontiers in cardiovascular medicine · 2018Review
- Formation of a TBX20-CASZ1 protein complex is protective against dilated cardiomyopathy and critical for cardiac homeostasis.PLoS genetics · 2017Article
- Use of Coronary Ultrasound Imaging to Evaluate Ventricular Function in Adult Zebrafish.Zebrafish · 2016Article
- Insulin-like growth factors and their potential role in cardiac epigenetics.Journal of cellular and molecular medicine · 2016Review
- Cardiac and somatic parameters in zebrafish: tools for the evaluation of cardiovascular function.Fish physiology and biochemistry · 2016Article
- Zebrafish heart as a model for human cardiac electrophysiology.Channels (Austin, Tex.) · 2016Review
- Article
- Loss of dihydrolipoyl succinyltransferase (DLST) leads to reduced resting heart rate in the zebrafish.Basic research in cardiology · 2015Article
- Fish is Fish: the use of experimental model species to reveal causes of skeletal diversity in evolution and disease.Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology · 2014Article
- Genetics and disease of ventricular muscle.Cold Spring Harbor perspectives in medicine · 2014Review
- Article
- New and TALENted genome engineering toolbox.Circulation research · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular disease (CVD) has recently overtaken infectious disease to become the biggest global killer. Genetic factors have emerged as being of major importance in the pathogenesis of CVD. Owing to disease heterogeneity, variable penetrance and high mortality, human genetic studies alone are not sufficient to elucidate the genetic basis of CVD. Animal models are needed to identify novel genes that are involved in cardiovascular pathology and to verify the effect of suspected disease genes on cardiovascular function. An intriguing model organism is the zebrafish danio rerio. Several features of the zebrafish, such as a closed cardiovascular system, transparency at embryonal stages, rapid and external development, and easily tractable genetics make it ideal for cardiovascular research. Moreover, zebrafish are suitable for forward genetics approaches, which allow the unbiased identification of novel and unanticipated cardiovascular genes. Zebrafish mutants with various cardiovascular phenotypes that closely correlate with human disease, such as congenital heart disease, cardiomyopathies and arrhythmias, have been isolated. The pool of zebrafish mutants, for which the causal gene mutation has been identified, is constantly growing. The human orthologues of several of these zebrafish genes have been shown to be involved in the pathogenesis of human CVD. Cardiovascular zebrafish models also provide the opportunity to develop and test novel therapeutic strategies, using innovative technologies such as high throughput in vivo small molecule screens.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.