ArticleMediators of inflammation2008
Production of nitric oxide and expression of inducible nitric oxide synthase in ovarian cystic tumors.
Article in Mediators of inflammation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 33 citations in OpenAlex.
- Bioactive constituents from the edible seaweedPharmaceutical biology · 2025Article
- Biologically active withanolides fromPharmaceutical biology · 2025Article
- Modulation of heme peroxo nucleophilicities with axial ligands reveal key insights into the mechanistic landscape of nitric oxide synthase.Chemical science · 2025Article
- Article
- Insights into the Role of Oxidative Stress in Ovarian Cancer.Oxidative medicine and cellular longevity · 2021Review
- The Potential Role of iNOS in Ovarian Cancer Progression and Chemoresistance.International journal of molecular sciences · 2019Review
- Role of the Nervous System in Tumor Angiogenesis.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2018Review
- The Daniel K. Inouye College of Pharmacy Scripts: Poha Berry (Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health · 2016Article
- Preclinical therapeutic potential of a nitrosylating agent in the treatment of ovarian cancer.PloS one · 2014Article
- Macrophage-tumor cell interactions regulate the function of nitric oxide.Frontiers in physiology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor sections from nonneoplastic (n = 15), benign (n = 28), and malignant ovarian tumors (n = 20) were obtained from 63 women. Immunohistochemistry of the tumor sections demonstrated that inducible nitric oxide synthase (iNOS) expression was increased in ovarian cancer samples compared to nonneoplastic or benign tumor samples. Using the Griess method, nitric oxide (NO) metabolite levels were also found to be elevated in malignant tumor samples compared to benign tumor samples (P < .05). For stage I ovarian cancer, intracystic NO levels >80 microM were more frequent than NO levels <80 microM, and iNOS expression in well-differentiated carcinomas was greater than in moderately/poorly differentiated carcinomas (P < .05). These data suggest an important role for NO in ovarian carcinogenesis.
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Registered trials
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