ArticlePloS one2009
Role of visible light-activated photocatalyst on the reduction of anthrax spore-induced mortality in mice.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- TiOInternational journal of molecular sciences · 2026Article
- Dachshund Homolog 1: Unveiling Its Potential Role in Megakaryopoiesis andInternational journal of molecular sciences · 2024Article
- Exposure to low levels of photocatalytic TiOScientific reports · 2022Article
- Exposure of Platelets to Dengue Virus and Envelope Protein Domain III Induces Nlrp3 Inflammasome-Dependent Platelet Cell Death and Thrombocytopenia in Mice.Frontiers in immunology · 2021Article
- Opportunistic gill infection is associated with TiO2 nanoparticle-induced mortality in zebrafish.PloS one · 2021Article
- Soluble P-selectin rescues mice from anthrax lethal toxin-induced mortality through PSGL-1 pathway-mediated correction of hemostasis.Virulence · 2017Article
- Visible Light-Responsive Platinum-Containing Titania Nanoparticle-Mediated Photocatalysis Induces Nucleotide Insertion, Deletion and Substitution Mutations.Nanomaterials (Basel, Switzerland) · 2016Article
- Antibacterial Properties of Visible-Light-Responsive Carbon-Containing Titanium Dioxide Photocatalytic Nanoparticles against Anthrax.Nanomaterials (Basel, Switzerland) · 2016Article
- Comparison of Infectious Agents Susceptibility to Photocatalytic Effects of Nanosized Titanium and Zinc Oxides: A Practical Approach.Nanoscale research letters · 2015Article
- Antibacterial property of Ag nanoparticle-impregnated N-doped titania films under visible light.Scientific reports · 2015Article
- Nanodiamonds protect skin from ultraviolet B-induced damage in mice.Journal of nanobiotechnology · 2015Article
- Acquired coagulant factor VIII deficiency induced by Bacillus anthracis lethal toxin in mice.Virulence · 2015Article
- Can biowarfare agents be defeated with light?Virulence · 2013Review
- Article
- Activated protein C ameliorates Bacillus anthracis lethal toxin-induced lethal pathogenesis in rats.Journal of biomedical science · 2012Article
- The use of nanoscale visible light-responsive photocatalyst TiO2-Pt for the elimination of soil-borne pathogens.PloS one · 2012Article
- Visible light responsive photocatalyst induces progressive and apical-terminus preferential damages on Escherichia coli surfaces.PloS one · 2011Article
- In vitro studies of peptidoglycan binding and hydrolysis by the Bacillus anthracis germination-specific lytic enzyme SleB.Journal of bacteriology · 2011Article
- Sublethal doses of anthrax lethal toxin on the suppression of macrophage phagocytosis.PloS one · 2010Article
- Bactericidal performance of visible-light responsive titania photocatalyst with silver nanostructures.PloS one · 2010Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhotocatalysis of titanium dioxide (TiO(2)) substrates is primarily induced by ultraviolet light irradiation. Anion-doped TiO(2) substrates were shown to exhibit photocatalytic activities under visible-light illumination, relative environmentally-friendly materials. Their anti-spore activity against Bacillus anthracis, however, remains to be investigated. We evaluated these visible-light activated photocatalysts on the reduction of anthrax spore-induced pathogenesis. METHODOLOGY/PRINCIPAL
findingsStandard plating method was used to determine the inactivation of anthrax spore by visible light-induced photocatalysis. Mouse models were further employed to investigate the suppressive effects of the photocatalysis on anthrax toxin- and spore-mediated mortality. We found that anti-spore activities of visible light illuminated nitrogen- or carbon-doped titania thin films significantly reduced viability of anthrax spores. Even though the spore-killing efficiency is only approximately 25%, our data indicate that spores from photocatalyzed groups but not untreated groups have a less survival rate after macrophage clearance. In addition, the photocatalysis could directly inactivate lethal toxin, the major virulence factor of B. anthracis. In agreement with these results, we found that the photocatalyzed spores have tenfold less potency to induce mortality in mice. These data suggest that the photocatalysis might injury the spores through inactivating spore components. CONCLUSION/SIGNIFICANCE: Photocatalysis induced injuries of the spores might be more important than direct killing of spores to reduce pathogenicity in the host.
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