ArticlePLoS pathogens2009
Genomic survey of the non-cultivatable opportunistic human pathogen, Enterocytozoon bieneusi.
Article in PLoS pathogens, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
63 citing papers in PubMed, 135 citations in OpenAlex.
- Identification of natural products and synthetic analogs which inhibit microsporidia spores and prevent infection.Journal of invertebrate pathology · 2026Article
- Identification of two new genetic loci for high-resolution genotyping of Enterocytozoon bieneusi.Parasite (Paris, France) · 2025Article
- Molecular epidemiology of Enterocytozoon bieneusi from foxes and raccoon dogs in the Henan and Hebei provinces in China.BMC veterinary research · 2024Article
- MicroAnnot: A Dedicated Workflow for Accurate Microsporidian Genome Annotation.International journal of molecular sciences · 2024Article
- Biogenesis, inheritance, and 3D ultrastructure of the microsporidian mitosome.Life science alliance · 2024Article
- A Putative TRAPα Protein of MicrosporidiaJournal of fungi (Basel, Switzerland) · 2023Article
- Comparative Genomics of Microsporidia.Experientia supplementum (2012) · 2022Article
- Identification and Characterization of Three Spore Wall Proteins ofFrontiers in cellular and infection microbiology · 2022Article
- A Perspective on the Molecular Identification, Classification, and Epidemiology of Enterocytozoon bieneusi of Animals.Experientia supplementum (2012) · 2022Article
- Ecological and public health significance ofOne health (Amsterdam, Netherlands) · 2021Review
- Innate and Adaptive Immune Responses Against Microsporidia Infection in Mammals.Frontiers in microbiology · 2020Review
- Chromulinavorax destructans, a pathogen of microzooplankton that provides a window into the enigmatic candidate phylum Dependentiae.PLoS pathogens · 2019Article
- Diversity and Evolution of Sensor Histidine Kinases in Eukaryotes.Genome biology and evolution · 2019Article
- Multilocus Sequence Typing and Population Genetic Analysis ofFrontiers in genetics · 2019Article
- Improved prediction of fungal effector proteins from secretomes with EffectorP 2.0.Molecular plant pathology · 2018Article
- Error-prone protein synthesis in parasites with the smallest eukaryotic genome.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- First detection and genetic characterisation of Enterocytozoon bieneusi in wild deer in Melbourne's water catchments in Australia.Parasites & vectors · 2018Article
- Domestication of self-splicing introns during eukaryogenesis: the rise of the complex spliceosomal machinery.Biology direct · 2017Review
- Fungal Genomes and Insights into the Evolution of the Kingdom.Microbiology spectrum · 2017Article
- Phylogenomic evolutionary surveys of subtilase superfamily genes in fungi.Scientific reports · 2017Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
Abstract
Enterocytozoon bieneusi is the most common microsporidian associated with human disease, particularly in the immunocompromised population. In the setting of HIV infection, it is associated with diarrhea and wasting syndrome. Like all microsporidia, E. bieneusi is an obligate, intracellular parasite, but unlike others, it is in direct contact with the host cell cytoplasm. Studies of E. bieneusi have been greatly limited due to the absence of genomic data and lack of a robust cultivation system. Here, we present the first large-scale genomic dataset for E. bieneusi. Approximately 3.86 Mb of unique sequence was generated by paired end Sanger sequencing, representing about 64% of the estimated 6 Mb genome. A total of 3,804 genes were identified in E. bieneusi, of which 1,702 encode proteins with assigned functions. Of these, 653 are homologs of Encephalitozoon cuniculi proteins. Only one E. bieneusi protein with assigned function had no E. cuniculi homolog. The shared proteins were, in general, evenly distributed among the functional categories, with the exception of a dearth of genes encoding proteins associated with pathways for fatty acid and core carbon metabolism. Short intergenic regions, high gene density, and shortened protein-coding sequences were observed in the E. bieneusi genome, all traits consistent with genomic compaction. Our findings suggest that E. bieneusi is a likely model for extreme genome reduction and host dependence.
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