SynthesisStroke2009
A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
Synthesis in Stroke, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Apolipoprotein EDisease markers · 2022Pooled it
- The association of MTHFR C677T variant with increased risk of ischemic stroke in the elderly population: a meta-analysis of observational studies.BMC geriatrics · 2019Pooled it
- Paraoxonase 1 polymorphisms and ischemic stroke risk: A systematic review and meta-analysis.Genetics in medicine : official journal of the American College of Medical Genetics · 2010Pooled it
- Implications of lipoprotein (a) [Lp(a)] gene polymorphic sequence variations and its protein expression in venous thromboembolism (VTE).Biochemistry and biophysics reports · 2025Article
- Article
- The effect of βWorld journal of urology · 2021Observational
- Variants inInternational journal of general medicine · 2021Article
- Association between lipoprotein(a) (Lp(a)) levels and Lp(a) genetic variants with coronary artery calcification.BMC medical genetics · 2020Article
- Genetic Factors of Nitric Oxide's System in Psychoneurologic Disorders.International journal of molecular sciences · 2020Review
- The Association of SNPs Located in the CDKN2B-AS1 and LPA Genes With Carotid Artery Stenosis and Atherogenic Stroke.Frontiers in neurology · 2019Article
- A meta-analysis of PDE-gene polymorphism and cerebral infarction risk.Experimental and therapeutic medicine · 2017Article
- Vascular Genetic Variants and Ischemic Stroke Susceptibility in Albanians from the Republic of Macedonia.Open access Macedonian journal of medical sciences · 2016Article
- IL-6 Variants in Ischemic Stroke.Annals of neurosciences · 2016Article
- Vitamin D, vitamin D binding protein gene polymorphisms, race and risk of incident stroke: the Atherosclerosis Risk in Communities (ARIC) study.European journal of neurology · 2015Article
- Race and Vitamin D Binding Protein Gene Polymorphisms Modify the Association of 25-Hydroxyvitamin D and Incident Heart Failure: The ARIC (Atherosclerosis Risk in Communities) Study.JACC. Heart failure · 2015Article
- Tumor necrosis factor beta NcoI polymorphism (rs909253) is associated with inflammatory and metabolic markers in acute ischemic stroke.Metabolic brain disease · 2015Article
- Association between PON1 L55M polymorphism and ischemic stroke: a systematic review and meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Epigenetic patterns of two gene promoters (TNF-α and PON) in stroke considering obesity condition and dietary intake.Journal of physiology and biochemistry · 2014Article
- Association of CVD candidate gene polymorphisms with ischemic stroke and cerebral hemorrhage in Chinese individuals.PloS one · 2014Article
- Association of inflammatory gene polymorphisms with ischemic stroke in a Chinese Han population.Journal of neuroinflammation · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 1 institution in 4 countries.
Funding
Abstract
background and purposeIschemic stroke is a multifactorial disease with a strong genetic component. Pathways, including lipid metabolism, systemic chronic inflammation, coagulation, blood pressure regulation, and cellular adhesion, have been implicated in stroke pathophysiology, and candidate gene polymorphisms in these pathways have been proposed as genetic risk factors.
methodsWe genotyped 105 simple deletions and single nucleotide polymorphisms from 64 candidate genes in 3550 patients and 6560 control subjects from 6 case-control association studies conducted in the United States, Europe, and China. Genotyping was performed using the same immobilized probe typing system and meta-analyses were based on summary logistic regressions for each study. The primary analyses were fixed-effects meta-analyses adjusting for age and sex with additive, dominant, and recessive models of inheritance.
resultsAlthough 7 polymorphisms showed a nominal additive association, none remained statistically significant after adjustment for multiple comparisons. In contrast, after stratification for hypertension, 2 lymphotoxin-alpha polymorphisms, which are in strong linkage disequilibrium, were significantly associated among nonhypertensive individuals: LTA 252A>G (additive model; OR, 1.41 with 95% CI, 1.20 to 1.65; P=0.00002) and LTA 26Thr>Asn (OR, 1.19 with 95% CI, 1.06 to 1.34; P=0.003). LTA 252A>G remained significant after adjustment for multiple testing using either the false discovery rate or by permutation testing. The 2 single nucleotide polymorphisms showed no association in hypertensive subjects (eg, LTA 252A>G, OR, 0.93; 95% CI, 0.84 to 1.03; P=0.17).
conclusionsThese observations may indicate an important role of LTA-mediated inflammatory processes in the pathogenesis of ischemic stroke.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.