ArticleToxicological sciences : an official journal of the Society of Toxicology2009
Biomarkers of human exposure to acrylamide and relation to polymorphisms in metabolizing genes.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 67 citations in OpenAlex.
- Genotoxic and Mutagenic Effects of theToxins · 2023Article
- Exposure to environmental chemicals and cancer risk: epidemiological evidence from Japanese studies.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2023Review
- Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk.Foods (Basel, Switzerland) · 2022Review
- Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies.Toxics · 2022Article
- Article
- Cord blood acrylamide levels and birth size, and interactions with genetic variants in acrylamide-metabolising genes.Environmental health : a global access science source · 2021Article
- Article
- Validity of a Self-administered Food Frequency Questionnaire for the Estimation of Acrylamide Intake in the Japanese Population: The JPHC FFQ Validation Study.Journal of epidemiology · 2018Article
- Simple, selective and fast detection of acrylamide based on glutathioneRSC advances · 2018Article
- Dietary acrylamide intake and risk of breast cancer: The Japan Public Health Center-based Prospective Study.Cancer science · 2018Article
- The influence of single nucleotide polymorphisms on the association between dietary acrylamide intake and endometrial cancer risk.Scientific reports · 2016Article
- Causes of genome instability: the effect of low dose chemical exposures in modern society.Carcinogenesis · 2015Review
- Among 10 sociodemographic and lifestyle variables, smoking is strongly associated with biomarkers of acrylamide exposure in a representative sample of the U.S. Population.The Journal of nutrition · 2013Article
- Dietary acrylamide intake during pregnancy and fetal growth-results from the Norwegian mother and child cohort study (MoBa).Environmental health perspectives · 2013Article
- Biological monitoring for occupational acrylamide exposure from acrylamide production workers.International archives of occupational and environmental health · 2011Article
- Exposure of the U.S. population to acrylamide in the National Health and Nutrition Examination Survey 2003-2004.Environmental health perspectives · 2010Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acrylamide (AA) is formed in heat treated carbohydrate rich foods in the so-called Maillard reaction. AA is readily absorbed in the body and converted to glycidamide (GA) by epoxidation by the CYP2E1 (cytochrome P450 2E) enzyme. Both AA and GA may be detoxified through direct conjunction to glutathione by glutathione-S-transferases and GA by hydrolysis to glyceramide. Recently, we reported that biomarkers of AA exposure reflect intake of major food sources of AA; there were large interindividual variations in the blood ratio of GA-Hb/AA-Hb (GA- and AA-hemoglobin adducts). In this study we investigated whether the ratio of GA-Hb/AA-Hb in subjects could be related to polymorphic differences in genes coding for metabolizing enzymes CYP2E1, EPHX1 (microsomal epoxide hydrolase), GSTM1, GSTT1, and GSTP1, all being expected to be involved in the activation and detoxification of AA-associated adducts. We found significant associations between GSTM1 and GSTT1 genotypes and the ratio of GA-Hb/AA-Hb (p = 0.039 and p = 0.006, respectively). The ratio of GA-Hb/AA-Hb in individuals with the combined GSTM1- and GSTT1-null variants was significantly (p = 0.029) higher than those with the wild-type genotypes. Although the number of subjects was small, there were also significant associations with other combinations; CYP2E1 (Val179Val) plus GSTM1-null (p = 0.022); CYP2E1 (Val/Val), GSTM1-null plus GSTT1-null (p = 0.047); and CYP2E1 (Val/Val), GSTT1 null, EPHX1 (Tyr113Tyr) plus EPHX1 (His139Arg) (p = 0.018). Individuals with these combined genotypes had significantly higher blood ratio of GA-Hb/AA-Hb than other combinations. The observed associations correspond with what would be expected from the relative roles of these enzymes in activation and detoxification of AA, except for individuals with the EPHX1 (His139Arg) variant. The internal dose of genotoxic metabolite and also the concentration of AA in blood seem to be affected by these polymorphic genes. The genotypes and their combination may constitute useful biomarkers for the assessment of individual susceptibility to AA intake, and could add to the precision of epidemiological studies of dietary cancer.
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