ArticleGenes & development2009
Drosophila PTB promotes formation of high-order RNP particles and represses oskar translation.
Article in Genes & development, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
73 citing papers in PubMed, 115 citations in OpenAlex.
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- Review
- An architectural role of specific RNA-RNA interactions in oskar granules.Nature cell biology · 2024Article
- PTBP1 regulates injury responses and sensory pathways in adult peripheral neurons.Science advances · 2023Article
- Novel roles for RNA binding proteins squid, hephaesteus, and Hrb27C in Drosophila oogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Structural and functional organization of germ plasm condensates.The Biochemical journal · 2022Review
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- Patterning the Drosophila embryo: A paradigm for RNA-based developmental genetic regulation.Wiley interdisciplinary reviews. RNA · 2020Review
- Structural Insights into RNA Dimerization: Motifs, Interfaces and Functions.Molecules (Basel, Switzerland) · 2020Review
- Makorin 1 controls embryonic patterning by alleviating Bruno1-mediated repression of oskar translation.PLoS genetics · 2020Article
- Identification of novel regulators of dendrite arborization using cell type-specific RNA metabolic labeling.PloS one · 2020Article
- What Are 3' UTRs Doing?Cold Spring Harbor perspectives in biology · 2019Review
- Cell Cycle Kinase Polo Is Controlled by a Widespread 3' Untranslated Region Regulatory Sequence in Drosophila melanogaster.Molecular and cellular biology · 2019Article
- Asymmetric Inheritance of Cell Fate Determinants: Focus on RNA.Non-coding RNA · 2019Review
- Ciphers and Executioners: How 3'-Untranslated Regions Determine the Fate of Messenger RNAs.Frontiers in genetics · 2019Review
- Genetic screen identifies a requirement for SMN in mRNA localisation within the Drosophila oocyte.BMC research notes · 2018Article
- Review
- Translational repression of theRNA (New York, N.Y.) · 2017Article
13 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Local translation of asymmetrically enriched mRNAs is a powerful mechanism for functional polarization of the cell. In Drosophila, exclusive accumulation of Oskar protein at the posterior pole of the oocyte is essential for development of the future embryo. This is achieved by the formation of a dynamic oskar ribonucleoprotein (RNP) complex regulating the transport of oskar mRNA, its translational repression while unlocalized, and its translational activation upon arrival at the posterior pole. We identified the nucleo-cytoplasmic shuttling protein PTB (polypyrimidine tract-binding protein)/hnRNP I as a new factor associating with the oskar RNP in vivo. While PTB function is largely dispensable for oskar mRNA transport, it is necessary for translational repression of the localizing mRNA. Unexpectedly, a cytoplasmic form of PTB can associate with oskar mRNA and repress its translation, suggesting that nuclear recruitment of PTB to oskar complexes is not required for its regulatory function. Furthermore, PTB binds directly to multiple sites along the oskar 3' untranslated region and mediates assembly of high-order complexes containing multiple oskar RNA molecules in vivo. Thus, PTB is a key structural component of oskar RNP complexes that dually controls formation of high-order RNP particles and translational silencing.
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