ArticleJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2009
Left ventricular twist mechanics in a canine model of reversible congestive heart failure: a pilot study.
Article in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 27 citations in OpenAlex.
- Trial
- Role of Two-Dimensional Speckle-Tracking Echocardiography in Early Detection of Left Ventricular Dysfunction in Dogs.Animals : an open access journal from MDPI · 2021Review
- The Memory of the Heart.Journal of cardiovascular development and disease · 2018Review
- Left ventricular strain distribution in healthy dogs and in dogs with tachycardia-induced dilated cardiomyopathy.Cardiovascular ultrasound · 2013Article
- Left ventricular twist is load-dependent as shown in a large animal model with controlled cardiac load.Cardiovascular ultrasound · 2012Article
- Speckle myocardial imaging modalities for early detection of myocardial impairment in isolated left ventricular non-compaction.Heart (British Cardiac Society) · 2010Article
- A preliminary study on the evaluation of relationship between left ventricular torsion and cardiac cycle phase by two-dimensional ultrasound speckle tracking imaging.The international journal of cardiovascular imaging · 2009Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundLeft ventricular (LV) twist dynamics play an important role in LV systolic and diastolic function. The aim of this preliminary study was to investigate LV twist dynamics in a canine model of reversible congestive heart failure (CHF).
methodsPacing systems were implanted in adult dogs, and continuous chronic right ventricular pacing (230-250 beats/min) was applied until CHF induction. Pacing was then stopped to allow the heart to recover. Echocardiography and LV catheterization were performed at baseline, during CHF while pacing was temporarily switched off, and during recovery. LV twist was computed as the difference between apical and basal rotation measured using 2-dimensional speckle tracking. Torsion was further calculated as LV twist divided by the LV long axis. The untwisting rate was computed as the peak diastolic time derivative of twist.
resultsIn 6 dogs that completed the study, we found that CHF developed after 2 to 4 weeks of pacing, with LV end-diastolic volume, end-systolic volume, end-diastolic pressure, and the time constant of relaxation during isovolumic relaxation period (tau) all increasing significantly compared with baseline and recovering to normal levels 2 to 4 weeks after pacing was stopped. LV twist, torsion, and untwisting rate decreased significantly with CHF compared with baseline and improved during recovery from CHF.
conclusionLV twist dynamics reflect pacing-induced CHF and its reversal as assessed by echocardiographic speckle tracking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.