ArticleElectrophoresis2008
Internally calibrated quantification of protein analytes in human serum by fluorescence immunoassays in disposable elastomeric microfluidic devices.
Article in Electrophoresis, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- A Quantitative Point-of-Need Assay for the Assessment of Vitamin DScientific reports · 2017Trial
- Ferritin as a diagnostic point-of-care marker in iron deficiency anemia: a narrative review and clinical implications.Annals of translational medicine · 2026Review
- Advances in Microfluidics for Single Red Blood Cell Analysis.Biosensors · 2023Review
- A Solution to the Clearance Problem of Sacrificial Material in 3D Printing of Microfluidic Devices.Micromachines · 2022Article
- Graphene-Based Biosensor for Early Detection of Iron Deficiency.Sensors (Basel, Switzerland) · 2020Article
- Potential Point-of-Care Microfluidic Devices to Diagnose Iron Deficiency Anemia.Sensors (Basel, Switzerland) · 2018Review
- Protein Microarrays with Novel Microfluidic Methods: Current Advances.Microarrays (Basel, Switzerland) · 2014Review
- Microfluidic opportunities in the field of nutrition.Lab on a chip · 2013Review
- Miniaturized technology for protein and nucleic acid point-of-care testing.Translational research : the journal of laboratory and clinical medicine · 2012Review
- Microfluidic LIPS for serum antibody detection: demonstration of a rapid test for HSV-2 infection.Biomedical microdevices · 2011Article
- Internally calibrated quantification of VEGF in human plasma by fluorescence immunoassays in disposable elastomeric microfluidic devices.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2010Article
- The fundamental flaws of immunoassays and potential solutions using tandem mass spectrometry.Journal of immunological methods · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Herein we report on reliable reproducible quantification of protein analytes in human serum by fluorescence sandwich immunoassays in disposable PDMS microfluidic chips. The system requires 1,000 times less sample than typical clinical blood tests and is specifically shown to measure ferritin down to 250 pM in human serum. The in-built calibration method of spiking the serum with known concentrations of commercially available antigen avoids common sources of error and improves the reliability of the test results. The reported microfluidic system is an important new tool for fundamental scientific research, offering sensitive immunoassay measurements in small but complex biosamples. The system is also a further step towards comprehensive affordable "point-of-care" biomedical diagnostics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.