ArticleMolecular biology reports2009
Association study of a single nucleotide polymorphism in the exon 2 region of toll-like receptor 9 (TLR9) gene with susceptibility to systemic lupus erythematosus among Chinese.
Article in Molecular biology reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- Association analysis between the TLR9 gene polymorphism rs352140 and type 1 diabetes.Frontiers in endocrinology · 2023Article
- The tangled web of autoreactive B cells in malaria immunity and autoimmune disease.Trends in parasitology · 2022Review
- TLR4 and TLR9 polymorphisms are not associated with either rheumatoid arthritis or systemic lupus erythematosus in Mexican patients.Molecular biology reports · 2021Article
- Relevant genetic polymorphisms and kidney expression of Toll-like receptor (TLR)-5 and TLR-9 in lupus nephritis.Clinical and experimental immunology · 2017Article
- Genetic variant in CXCL13 gene is associated with susceptibility to intrauterine infection of hepatitis B virus.Scientific reports · 2016Article
- Toll-like receptors in systemic lupus erythematosus: potential for personalized treatment.Frontiers in pharmacology · 2014Article
- Contribution of toll-like receptor 9 gene single-nucleotide polymorphism to systemic lupus erythematosus.Rheumatology international · 2013Article
- Article
- TLR7 and TLR9 in SLE: when sensing self goes wrong.Immunologic research · 2012Review
- Involvement of Toll-like Receptor 9 polymorphism in cervical cancer development.Molecular biology reports · 2012Article
- Different genetic patterns in avian Toll-like receptor (TLR)5 genes.Molecular biology reports · 2012Article
- Genetics of SLE: functional relevance for monocytes/macrophages in disease.Clinical & developmental immunology · 2012Review
- Possible association of VISA gene polymorphisms with susceptibility to systemic lupus erythematosus in Chinese population.Molecular biology reports · 2011Article
- Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice.The Journal of clinical investigation · 2011Article
- Association of pre-microRNAs genetic variants with susceptibility in systemic lupus erythematosus.Molecular biology reports · 2011Article
- Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population.Arthritis research & therapy · 2011Article
- Toll-like receptor gene polymorphisms are associated with susceptibility to Graves' ophthalmopathy in Taiwan males.BMC medical genetics · 2010Article
- Nucleic acid sensing receptors in systemic lupus erythematosus: development of novel DNA- and/or RNA-like analogues for treating lupus.Clinical and experimental immunology · 2010Review
- Interferon alpha in systemic lupus erythematosus.Journal of biomedicine & biotechnology · 2010Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toll-like receptor 9 (TLR9) plays an important role in the induction and regulation of the innate immune system or adaptive immune responses. Genetic variations within human TLR9 have been reported to be associated with a range of immune-related diseases, such as asthma, systemic lupus erythematosus (SLE) and so on. Family-based association analysis was performed to further investigate whether a single nucleotide polymorphism (rs352140) in the exon 2 region of TLR9 gene is associated with susceptibility to SLE in a Chinese population. A total of 77 patients with SLE from 74 nuclear families, aged from 12 to 63 years, were enrolled according to 1997 criteria of American College of Rheumatology (ACR), 211 family members of these patients were also included. Genotyping was performed by PCR-restriction fragment length polymorphism (PCR-RFLP) assay. Among 77 patients with SLE, the CC, CT and TT genetype frequencies of the SNP (rs352140) were 20.8, 61.0 and 18.2%, respectively. Single loci analysis suggested that the T allele at position of rs352140 was significantly associated with the susceptibility to SLE (Z = 2.357, P = 0.018402) in dominant model, but not in additive or recessive model. Genetype analysis showed that individuals with CT genetype had greater susceptibility to SLE than those without (Z = 2.004, P = 0.045067). Our study suggests that a single nucleotide polymorphism (rs352140) in the exon 2 region of TLR9 gene may be a susceptibility factor for SLE in Chinese population.
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