Evidence map›Paper›PMID 19130262›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2009

Molecular and genetic characterization of the TonB2-cluster TtpC protein in pathogenic vibrios.

Carole J Kuehl, Jorge H Crosa

Open access · greenAbstract read
In one paragraph

Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Iron Acquisition Strategies ofFrontiers in cellular and infection microbiology · 2017
    Review
  3. Vibrio Iron Transport: Evolutionary Adaptation to Life in Multiple Environments.Microbiology and molecular biology reviews : MMBR · 2016
    Review
  4. Plasmid- and chromosome-encoded siderophore anguibactin systems found in marine vibrios: biosynthesis, transport and evolution.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2013
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Carole J KuehlDepartment of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA.
Jorge H Crosa
Oregon Health & Science University · US

Funding

IRON UPTAKE AS A VIRULENCE FACTOR IN PATHOGENIC VIBRIOSR01AI019018 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI CROSA, JORGE H · 1985 to 2011
$3.9M
Iron and pathogenesis in infections by Vibrio vulnificusR01AI065981 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI CROSA, JORGE H · 2007 to 2011
$2.1M
NIAID NIH HHS R01 AI019018NIAID NIH HHS R01 AI065981
6 · The paper itself

Abstract

TtpC is a fourth required protein in the TonB2 energy transduction system in Vibrio anguillarum. TtpC is necessary for iron transport mediated by the TonB2 system and is highly conserved in all pathogenic vibrio species studied to date as well as several marine organisms. We show here that the TtpC proteins from selected pathogenic vibrio species can function with the TonB2 system of V. anguillarum to allow iron transport mediated by a chimeric TonB2 system where the native ExbB2, ExbD2 and TonB2 function with an episomally expressed TtpC in trans from a different species. The discovery that inter-species complementation occurs can be used to identify the functional regions of the TtpC proteins and will lead to an investigation of the mechanism of interaction between the TtpC protein and other members of the TonB2 system.

Indexed as

Bacterial ProteinsMembrane ProteinsAmino Acid SequenceBiological TransportGenetic Complementation TestIronMolecular Sequence DataMultigene FamilyPeptidesSequence AlignmentSiderophoresVibrioanguibactinBacterial ProteinsIronMembrane ProteinsPeptidesSiderophorestonB protein, Bacteria

Identifiers

PMID19130262
PMCPMC3032568
OpenAlexW2092760731

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.